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Journal of Neurology, Neurosurgery, and Psychiatry 1988;51:924-928; doi:10.1136/jnnp.51.7.924
Copyright © 1988 by the BMJ Publishing Group Ltd.

Withdrawal symptoms from phenytoin, carbamazepine and sodium valproate.

J S Duncan, S D Shorvon and M R Trimble

Institute of Neurology, National Hospital, London, UK.

A prospective, double-blind, placebo-controlled investigation of possible withdrawal symptoms from phenytoin, carbamazepine and sodium valproate is reported in patients with active epilepsy, on combination therapy. There was an increase in seizures on reduction and withdrawal of carbamazepine, but there was no convincing evidence of withdrawal symptoms from any of these drugs.


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