Ischaemic brain damage is still common in fatal non-missile head injury.
Department of Neuropathology, University of Glasgow, Scotland, UK.
A detailed neuropathological examination has been undertaken on a consecutive series of head injuries dying in the Institute of Neurological Sciences, Glasgow, between 1968-72 (151 cases) and 1981-82 (112 cases) in order to determine the frequency and distribution of any ischaemic brain damage. Ischaemic damage was found in the brains of 92% of the 1968-72 cases and in 88% of the 1981-82 cases: there was no statistical difference in the amount of moderately severe and severe ischaemic damage in the two groups, 55% and 54% respectively. There was evidence, however, that an increased number of patients with severe ischaemic brain damage was admitted in 1981-82 as a result of a changed admission policy of the Department of Neurosurgery that resulted in an increased detection of intracranial haematomas. It is concluded that ischaemic brain damage is still common after severe head injury, and it seems likely that it remains an important cause of mortality and morbidity.
This article has been cited by other articles:
-
Moppett, I. K.
(2007). Traumatic brain injury: assessment, resuscitation and early management. Br J Anaesth
99: 18-31
[Abstract] [Full Text] -
Kirkness, C. J., Burr, R. L., Cain, K. C., Newell, D. W., Mitchell, P. H.
(2006). Effect of Continuous Display of Cerebral Perfusion Pressure on Outcomes in Patients With Traumatic Brain Injury. Am J Crit Care
15: 600-609
[Abstract] [Full Text] -
Marino, R., Gasparotti, R., Pinelli, L., Manzoni, D., Gritti, P., Mardighian, D., Latronico, N.
(2006). Posttraumatic cerebral infarction in patients with moderate or severe head trauma.. Neurology
67: 1165-1171
[Abstract] [Full Text] -
Smith, C, Graham, D I, Murray, L S, Stewart, J, Nicoll, J A R
(2006). Association of APOE e4 and cerebrovascular pathology in traumatic brain injury.. J. Neurol. Neurosurg. Psychiatry
77: 363-366
[Abstract] [Full Text] -
Cunningham, A. S., Salvador, R., Coles, J. P., Chatfield, D. A., Bradley, P. G., Johnston, A. J., Steiner, L. A., Fryer, T. D., Aigbirhio, F. I., Smielewski, P., Williams, G. B., Carpenter, T. A., Gillard, J. H., Pickard, J. D., Menon, D. K.
(2005). Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury. Brain
128: 1931-1942
[Abstract] [Full Text] -
Smith, M.
(2003). Diffuse axonal injury in adults. Trauma
5: 227-234
[Abstract] -
Vanderheyden, B. A., Buck, B. D.
(2002). Management of Elevated Intracranial Pressure. Journal of Pharmacy Practice
15: 167-185
[Abstract] -
Adams, J H., Graham, D I, Jennett, B
(2001). The structural basis of moderate disability after traumatic brain damage. J. Neurol. Neurosurg. Psychiatry
71: 521-524
[Abstract] [Full Text] -
Manley, G., Knudson, M. M., Morabito, D., Damron, S., Erickson, V., Pitts, L.
(2001). Hypotension, Hypoxia, and Head Injury: Frequency, Duration, and Consequences. Arch Surg
136: 1118-1123
[Abstract] [Full Text] -
Hong, Z., Xinding, Z., Tianlin, Z., Liren, C.
(2001). Excitatory Amino Acids in Cerebrospinal Fluid of Patients with Acute Head Injuries. Clin. Chem.
47: 1458-1462
[Abstract] [Full Text] -
Armstead, W. M.
(2001). Vasopressin-Induced Protein Kinase C-Dependent Superoxide Generation Contributes to ATP-Sensitive Potassium Channel but Not Calcium-Sensitive Potassium Channel Function Impairment After Brain Injury. Stroke
32: 1408-1414
[Abstract] [Full Text] -
Jennett, B., Adams, J. H., Murray, L. S., Graham, D. I.
(2001). Neuropathology in vegetative and severely disabled patients after head injury. Neurology
56: 486-490
[Abstract] [Full Text] -
Adams, J. H., Graham, D. I., Jennett, B.
(2000). The neuropathology of the vegetative state after an acute brain insult. Brain
123: 1327-1338
[Abstract] [Full Text] -
Shackford, S. R., Mackersie, R. C., Holbrook, T. L., Davis, J. W., Hollingsworth-Fridlund, P., Hoyt, D. B, Wolf, P. L.
(1993). The Epidemiology of Traumatic Death: A Population-Based Analysis. Arch Surg
128: 571-575
[Abstract]
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
