JNNP

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
This Article
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Strong, A. J.
Right arrow Articles by Ross-Field, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Strong, A. J.
Right arrow Articles by Ross-Field, L.

Journal of Neurology, Neurosurgery, and Psychiatry, 1990, Vol 53, 847-853

PAPERS

Insulin protects cognitive function in experimental stroke

AJ Strong, JE Fairfield, E Monteiro, M Kirby, AR Hogg, M Snape and L Ross-Field
Neurosurgery Research Group, Institute of Psychiatry, London, United Kingdom.

There is evidence from in vitro systems that the extent of neuronal loss in acute central nervous system ischaemia can be reduced by manoeuvres which restrict availability of glucose to the ischaemic area. Experiments were designed to test whether hypoglycaemia induced with insulin is associated with improved behavioural outcome in a recovery model of stroke. Rats learned a maze task as a test of working memory, believed to be subserved by the hippocampus, and then had a period of cerebral ischaemia, followed by reperfusion. After an interval of 14 days they were tested on the same maze, where lesioned animals had very significant (p less than 0.0001) impairment of working memory, whereas lesioned and treated (2.0 u/kg-1 insulin, minimum single plasma glucose value: 3.1 mmol/l-1) animals were indistinguishable from control animals. It is concluded that a striking degree of protection can be obtained with levels of mild hypoglycaemia which may be acceptable and practicable for use in humans.

© 1990 by Journal of Neurology, Neurosurgery, and Psychiatry



This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
L. L. Guyot, F. G. Diaz, M. H. O'regan, D. Song, and J. W. Phillis
Topical Insulin and Accumulation of Excitotoxic and Other Amino Acids in Ischemic Rat Cerebral Cortex
Experimental Biology and Medicine, May 1, 2000; 224(1): 28 - 31.
[Abstract] [Full Text]

Home page
 Physiol. Rev.Home page
P. Lipton
Ischemic Cell Death in Brain Neurons
Physiol Rev, October 1, 1999; 79(4): 1431 - 1568.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
R. L. Tyson, G. R. Sutherland, and J. Peeling
23Na Nuclear Magnetic Resonance Spectral Changes During and After Forebrain Ischemia in Hypoglycemic, Normoglycemic, and Hyperglycemic Rats
Stroke, May 1, 1996; 27(5): 957 - 964.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 1990 by the BMJ Publishing Group Ltd.