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Journal of Neurology, Neurosurgery, and Psychiatry, 1990, Vol 53, 854-855

PAPERS

Platelet monoamine oxidase B activity in parkinsonian patients

U Bonuccelli, P Piccini, P Del Dotto, GM Pacifici, GU Corsini and A Muratorio
Institute of Clinical Neurology, University of Pisa, Italy.

Monoamine oxidase B (MAO B) plays a pivotal role in N-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) induced Parkinsonism. An increased MAO B activity in platelets of patients with idiopathic Parkinson's disease (PD) is reported in this study. The possibility that high MAO B activity may represent a trait of vulnerability for PD by enhancing the neurotoxic effects of environmental compounds is discussed.

© 1990 by Journal of Neurology, Neurosurgery, and Psychiatry



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