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Journal of Neurology, Neurosurgery, and Psychiatry, 1993, Vol 56, 1207-1212

PAPERS

Delirium associated with Joseph disease

Y Fukutani, K Katsukawa, R Matsubara, K Kobayashi, I Nakamura and N Yamaguchi
Division of Neuropsychiatry, National Sanatorium Hokuriku Hospital, Toyama, Japan.

Three Japanese patients with Joseph disease from different families developed sleep disturbance, followed by delirium at the middle to end stage. Brain CT scans of the three patients showed brainstem tegmental atrophy. EEG revealed slowing of background activity. Two necropsy cases showed degeneration of the reticular formation, raphe nuclei and locus ceruleus in the brainstem tegmentum in addition to the common pathological findings of Joseph disease. The clinicopathological correlation between the delirium and the brainstem tegmental atrophy in Joseph disease is discussed.

© 1993 by Journal of Neurology, Neurosurgery, and Psychiatry



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[Abstract] [Full Text] [PDF]


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