Short report
Hypofunction in the posterior cingulate gyrus correlates with
disorientation for time and place in Alzheimer's disease
a Department of Clinical
Neurosciences, b Department of Neuroimaging Research, Hyogo Institute
for Aging Brain and Cognitive Disorders, Saisho-ko, Himeji, Japan
Correspondence to: Dr Nobutsugu Hirono, Department of Clinical Neuroscience, Hyogo Institute for Aging Brain and Cognitive Disorders, 520 Saisho-ko, Himeji, 670 Japan. Telephone 0081 792 95 5511; fax 0081 792 95 8199; email hirono{at}hiabcd.gojp
Received 22 May 1997 and in revised form 11 September 1997;
Accepted 25 September 1997
The relation between orientation for time and place and
regional cerebral glucose metabolism was examined in 86 patients with probable Alzheimer's disease of minimal to moderate severity. Regional
glucose metabolic rates in the posterior cingulate gyri and in the
right middle temporal gyrus were significantly correlated with temporal
orientation, and the glucose metabolic rate in the right posterior
cingulate gyrus was significantly correlated with locational
orientation irrespective of age, sex, education, and memory impairment.
The results suggest that dysfunction of these structures plays an
important part in producing disorientation in patients with
Alzheimer's disease.
© 1998 by Journal of Neurology, Neurosurgery, and Psychiatry
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