| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
Second Department of
Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka,
Japan
Correspondence to: Dr Hiroshi Nakane, Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Maidashi 3-1-1, Fukuoka 812, Japan. Telephone 0081 92 642 5271; fax 0081 92 632 2551.
Received 10
September 1997 and in revised form 5 January 1998;
Accepted 14
January 1998
OBJECTIVES
Silent
brain infarction (SBI) is of growing interest as a possible risk factor
for symptomatic stroke. Although morphological characteristics of SBI
have been well defined, their characteristic patterns of cerebral blood
flow (CBF) and metabolism are in dispute. The purpose of this study was
to elucidate CBF and metabolism in patients with SBI in relation to
symptomatic stroke.
METHODSThe patients
underwent PET and were separated into three groups; control group (C
group), with no lesions on CT (n=9, mean age 57), SBI group, with no
neurological signs or history of stroke, but with ischaemic lesions on
CT (n=9, mean age 63), and brain infarction group (BI group), with
neurological deficits and compatible CT lesions in the area supplied by
perforating arteries (n=19, mean age 56). Regional CBF, oxygen
extraction fraction (OEF), cerebral metabolic rate for oxygen
(CMRO2), and cerebral blood volume (CBV) were measured by PET.
RESULTSMean values
for CBF to the cerebral cortex and deep grey matter were lower in the
SBI group (31.6 (SD 5.8) and 34.3 (SD 6.9) ml/100 g/min, respectively)
and in the BI group (30.8 (SD 5.2), 33.9 (SD 5.9), respectively) than
in the C group (36.0 (SD 6.6) and 43.5 (SD 9.5), respectively).
Although mean CMRO2 of deep grey matter (2.36 (SD 0.52)
ml/100 g/min) was significantly decreased in the SBI group compared
with the C group (2.76 (SD 0.480), p<0.01), CMRO2 of the
cortical area was as well preserved in the SBI patients (2.36 (SD
0.39)) as in the controls (2.48 (SD 0.32)) with a compensatory increase
of mean OEF (0.45 (SD 0.06) and 0.41 (SD 0.05), respectively).
CONCLUSIONSPatients
with SBI showed decreased CBF and CMRO2 in deep grey
matter. On the other hand, decreased CBF with milder increased OEF,
resulting in preserved CMRO2 in the cerebral cortex
indicates the presence of occult misery perfusion, suggesting that
patients with SBI have reduced cerebral perfusional reserves.
This article has been cited by other articles:
|
|
 |
|
  A. Spilt, A. W. E. Weverling-Rijnsburger, H. A. M. Middelkoop, W. M. van Der Flier, J. Gussekloo, A. J. M. de Craen, E. L. E. M. Bollen, G. J. Blauw, M. A. van Buchem, and R. G. J. Westendorp Late-Onset Dementia: Structural Brain Damage and Total Cerebral Blood Flow Radiology, September 1, 2005; 236(3): 990 - 995. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
