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a Department of
Psychology, University of Turin, and Istituto Nazionale Neurologico C
Besta, Milan, Italy, b Divisione di Neurologia, Ospedale Niguarda,
Milan, Italy, and MRC Cyclotron Unit, Hammersmith Hospital, London, UK, c Divisione di Neurologia,
Ospedale Niguarda, Milan, Italy
Correspondence to: Dr Giuliano Geminiani, Istituto Nazionale Neurologico C Besta, via Celoria 11, 20133 Milano, Italy.
Received 2 January
1996 and in revised form 13 February 1998;
Accepted 24 February 1998
OBJECTIVE
To explore
the hypothesis that dopaminergic circuits play a part in the premotor
components of the unilateral neglect syndrome, the effects of acute
dopaminergic stimulation in patients with neglect were studied.
METHODSTwo tasks were
evaluated before and after subcutaneous administration of apomorphine
and placebo: a circle crossing test and a test of target exploration (a
modified version of the bell test), performed both in perceptual
(counting) and in perceptual-motor (pointing) conditions.
SUBJECTSFour patients
with left neglect.
RESULTSAfter
dopaminergic stimulation, a significant improvement was found compared
with placebo administration and baseline evaluation, in the performance
of the two tests. Three of the patients had a more marked improvement
in the perceptual-motor condition (pointing) of the task than the
perceptual condition (counting).
CONCLUSIONSThe
findings suggest that dopaminergic neuronal networks may mediate, in
different ways, both perceptive and premotor components of the
unilateral neglect syndrome.
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