Short report
The role of the 
-synuclein gene mutation in patients with
sporadic Parkinson's disease in the United Kingdom
University
Department of Clinical Neurosciences, Royal Free Hospital School of
Medicine, Rowland Hill Street, London, UK
Correspondence to: Dr T T Warner, University Department of Clinical Neurosciences, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF, UK.
Received 21
November 1997 and in revised form 9 February 1998;
Accepted 16
February
Parkinson's disease is a common neurodegenerative disorder of
unknown aetiology. A pathogenic point mutation within the 
-synuclein gene has recently been identified in one Italian-American kindred and
three families of Greek origin with parkinsonism. DNA from 70 patients
with Parkinson's disease was screened for this G209A mutation. No
samples were positive for the mutation, suggesting that it is not
relevant for most patients with sporadic idiopathic Parkinson's disease.
-synuclein gene
© 1998 by Journal of Neurology, Neurosurgery, and Psychiatry
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