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Quintiles, 3-5 rue Maurice Ravel, 92594 Levallois
Perret Cedex, France
Correspondence to: Dr Nuala Murphy, Quintiles, 3-5 rue Maurice Ravel, 92594 Levallois Perret Cedex, France. Fax 003 1 41 27 72 00.
Received 3 September 1997 and in revised form 16 December 1997;
Accepted 12 March 1998
OBJECTIVE
To assess the quality of life (QoL) of
patients with multiple sclerosis in France, Germany, and the United
Kingdom with a cross sectional study.
METHODSPatients were classified into three
severity groups according to the expanded disability severity scale
(EDSS); stage I, II, and III, corresponding to mild (EDSS 1.0-3.5),
moderate (EDSS 4.0-6.0), or severe (EDSS 6.5-8.0) multiple sclerosis
respectively. Ninety patients with multiple sclerosis and 30 control
patients without multiple sclerosis were recruited in each country.
Control patients were matched to the patients with multiple sclerosis according to age and sex. Quality of life was assessed using the functional status questionnaire (FSQ).
RESULTSThe aspects of QoL that were mostly
affected in the three countries under study were physical function and
general wellbeing. Social role function decreased with increased
severity of disease in France and in particular in Germany. Multiple
sclerosis did not seem to have an impact on psychological function. The
QoL of control patients was systematically higher than that of patients with multiple sclerosis.
CONCLUSIONSUse of such a generic scale showed
that progression of multiple sclerosis is accompanied by a decrease in
QoL and suggested that this could be a relevant measurement in
assessing the effect of treatment and progression of disease. Variation
between countries, however, may be important.
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