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a Faculty of
Health Sciences, La Trobe University, Melbourne, Australia, b Department of Neurology, Austin and Repatriation
Medical Centre, Studley Road, Heidelberg, Victoria, Australia, c Centre for the Study of Perceptuomotor Disorders,
St Vincent's Hospital, Melbourne, Australia, d Clinical Neurosciences, St
Vincent's Hospital, Melbourne, Australia, e Department of Psychology, University of
Melbourne, Australia
Correspondence to: Dr Kerry Bennett, Faculty of Health Sciences, La Trobe University, Bundoora, Victoria, Australia 3053. Telephone 0061 3 9479 5785.
Received 4 June 1997 and in revised form 7
January 1998;
Accepted 12 March 1998
OBJECTIVE
to assess postoperative effects of
unilateral posteroventral pallidotomy on the organisation of upper limb movement.
METHODSA three dimensional kinematic system
(ELITE, B|T|S| Italy) was used to record reach to grasp movements
to objects of either small (0.7 cm) or large (8 cm) diameter placed at
a reaching distance of either 20 or 30 cm. Four patients with
Parkinson's disease were assessed in "off" (12 hours without
medication) and "on" (1 hour after administration of medication)
preoperatively and postoperatively.
RESULTSDuration of the movement and the time
spent in arm deceleration were significantly reduced after surgery.
However, movement patterning according to object size was adversely
affected. Postoperatively, all four patients showed an abnormal pattern
of a longer movement duration, and three showed a longer time of
reaching arm deceleration, for reach to grasp movements to the large
object than for those to the small object.
CONCLUSIONPosteroventral pallidotomy seems to be
beneficial in reducing bradykinesia of upper limb movements but may
have "costs" to movement patterning, particularly for reach to
grasp movements to objects of differing sizes. This study raises
interesting questions about the role of the globus pallidus interna in
coordinating stimulus bound visual information with appropriate motor patterning.
This article has been cited by other articles:
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  J. A. Saint-Cyr, L. L. Trepanier, R. Kumar, A. M. Lozano, and A. E. Lang Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson's disease Brain, October 1, 2000; 123(10): 2091 - 2108. [Abstract] [Full Text] [PDF]
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