JNNP

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Guieu, R
Right arrow Articles by Jaquet, P
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Guieu, R
Right arrow Articles by Jaquet, P
J Neurol Neurosurg Psychiatry 1998;65:502-507 ( October )

The hormonal response to stress is not modified by the dramatic decrease in prolactin plasma concentration during surgery for microprolactinoma

R Guieu,a H Dufour,b C Devaux,a T Brue,c J P Rosso,e F Grisoli,b M Grino,f A Enjalbert,c D Begoud,d N Broder,d H Rochat,a P Jaquetc

a Laboratoire de Biochimie, Faculté de Médecine Secteur Nord, UMR CNRS 6560, Institut Fédératif J Roche, Bd P Dramard 13015, Marseille, France, b Service de Neurochirurgie, c Service d'Endocrinologie, CHU Timone Adultes, d Département d'Anesthesie, CHU Timone, Bd J Moulin 13005, Marseille, France, e Labortatoire de Biochimie, f Service d'Endocrinologie, Hopital Nord Bd P Dramard 13015, Marseille, France

Correspondence to: Dr R Guieu, Laboratoire de Biochimie, Faculté de Médecine Secteur Nord, UMR CNRS 6560, Institut Fédératif J Roche, Bd P Dramard 13015, Marseille, France. Fax 0033 04 91 65 75 95.

Received 14 October 1997 and in revised form 1 December 1997; Accepted 4 December 1997

OBJECTIIVES---To determine the endocrine response to surgical stress in a homogeneous population of 36 women with microprolactinomas, particularly to evaluate the effect of the sharp decrease in plasma prolactin on stress induced hormonal secretion. In addition, the effects of exogenous opiates on prolactin secretion were studied.
METHODS---The plasma kinetics of cortisol, prolactin, ACTH, GH, and beta -endorphin like immunoreactivity (beta -ELI) were analysed by including patients operated on with strict anaesthetic and surgical protocols, and by sampling blood every 10 minutes, starting at premedication up to 3 hours after induction.
RESULTS AND CONCLUSIONS---(a) Surgical stress or opiate administration did not induce prolactin release in patients with microprolactinoma. (b) The dramatic decrease in prolactin concentrations have apparently no effect on the release of other hormones involved in stress. (c) The existence of an early GH peak, independently of any surgical procedure, strongly suggests that GH is released by surgical stress whereas beta -endorphin is secreted in response to pain. Thus GH may be a useful marker of surgical stress.

Keywords: anaesthesia; microprolactinomas; surgical stress; endorphins

© 1998 by Journal of Neurology, Neurosurgery, and Psychiatry


This article has been cited by other articles:


Home page
 Ann. Surg. Oncol.Home page
G. Shakhar and S. Ben-Eliyahu
Potential Prophylactic Measures Against Postoperative Immunosuppression: Could They Reduce Recurrence Rates in Oncological Patients?
Ann. Surg. Oncol., October 1, 2003; 10(8): 972 - 992.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 1998 by the BMJ Publishing Group Ltd.