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a Department of Geriatric Medicine, Prince of Wales and
Prince Henry Hospitals, Randwick, NSW 2031, Australia, b Department of Medicine, c Department of Community and Family Medicine, d Department of Chemical Pathology,
Chinese University of Hong Kong, Hong Kong, e United Christian Hospital, Hong Kong, f FAR, School of Mathematical Sciences,
University of Technology, Sydney, Broadway, NSW, Australia, g Shatin Hospital, Hong Kong
Correspondence to: Dr DKY Chan, Department of Geriatric Medicine, Parkes Block 2 East, Prince of Wales Hospital, High Street, Randwick, NSW 2031, Australia.
Received 18
April 1997 and in revised form 26 May 1998;
Accepted 26 May
1998
An epidemiological study of the environmental and genetic
factors as well as the possible interplay between them was conducted among 215 patients with Parkinson's disease and 313 controls in a
Chinese population in Hong Kong. In univariate analysis, a regular tea
drinking habit was found to be a protective factor, which had not been
reported before. Smoking (a protective factor), family history,
duration of pesticide exposure (in years) in farming and pesticide
exposure during farming in women (both risk factors) have been reported
previously. In multivariate analysis, current smoking reached
borderline significance at the 5% level and the variables, years
exposed to pesticides and family history were significant at the 10%
level. By contrast with the common occurrence of polymorphism of the
CYP2D6 gene (a gene involved with xenobiotic metabolism) in white
people, it is very rare in China and is not thought to be a significant
factor contributing to Parkinson's disease in Chinese people.
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