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a Department of Neurology, Norfolk and Norwich Health
Care NHS Trust, Norwich, UK, b Department of
Neurology, Addenbrooke's Hospital and MRC Cognition and Brain Sciences
Unit, Cambridge, UK
Correspondence to: Professor J R Hodges, MRC Cambridge Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, UK. Telephone 0044 1223 355294; fax 0044 1223 359062.
Received 6 June 1997 and in revised form 21
May 1998;
Accepted 15 June 1998
OBJECTIVES
To determine the prevalence and nature
of global cognitive dysfunction and language deficits in an unselected
population based cohort of patients with motor neuron disease (MND).
METHODSA battery of neuropsychological and
language tests was administered to patients presenting consecutively
over a 3 year period to a regional neurology service with a new
diagnosis of sporadic motor neuron disease.
RESULTSThe 18 patients could be divided on the
basis of their performance into three groups: Three patients were
demented and had impaired language function (group 1); two non-demented
patients had an aphasic syndrome characterised by word finding
difficulties and anomia (group 2). Major cognitive deficits were
therefore found in five of the 18 patients (28%). The remaining 13 performed normally on the test battery apart from decreased verbal
fluency (group 3).
CONCLUSIONSThe prevalence of cognitive impairment
in MND in this population based study of an unselected cohort was
higher than has been previously reported. Language deficits, especially
anomia, may be relatively frequent in the MND population. Aphasia in
MND may be masked by dysarthria and missed if not specifically examined.
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