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Department of
Medical and Molecular Genetics, Indiana University School of Medicine,
Indianapolis, IN, USA
Correspondence to: Department of Medical and Molecular Genetics, Indiana University School of Medicine, Medical Research and Library Building, IB 155, 975 W Walnut Street, Indianapolis, IN 46202, USA. Telephone 001 317 278 1291; fax 001 317 274 2387; email foroud{at}medgen.iupui.edu
Received 11 June 1998;
Accepted 3 August 1998
OBJECTIVES
Data from a
sample of 2494 patients affected with Huntington's disease (HD),
collected as part of the National Research Roster for Huntington
Disease Patients and Families, were examined to determine if there was
a relation between age at onset and duration of illness.
METHODSSufficient
data for inclusion in analysis was available from 2068 patients, of
whom 828 were deceased and 1240 were living. The median duration of
disease was 21.4 years with a range of 1.2 to 40.8 years. Patients were
categorised into one of four groups based on their age at onset.
RESULTSSignificant
differences in duration based on the age at onset were found
(p<0.025), with juvenile and late onset patients with HD having
shorter duration of illness compared with those with an onset between
20-49 years.
CONCLUSIONSDuration
of disease is influenced by the age at symptom onset with juvenile and
late onset patients having the shortest duration.
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