Review
Neuropsychological abnormalities in first degree relatives
of patients with familial Parkinson's disease
Kathy Dujardina b, Alain Duhamelc, Estelle Becqueta, Christine Grunberga, Luc Defebvrea, Alain Desteea
a CHRU de Lille,
Clinique Neurologique, Neurologie A, Hôpital R. Salengro, 59037 Lille
Cedex, France, b Université
Charles de Gaulle, Lille3, UFR de Psychologie, BP 149, 59653 Villeneuve
d'Ascq Cedex, France, c Université de Lille 2, Faculté de
Médecine, CERIM, 59037 Lille Cedex, France
Correspondence to: Dr Kathy Dujardin, Clinique Neurologique, Neurologie A, CHRU de Lille, Hôpital Salengro, 59037 Lille Cedex, France. Telephone 0033 320 44 67 52; fax 0033 320 44 66 80; email: kdujardin{at}nordnet.fr
Received 6 November
1998 and in revised form 31 March 1999;
Accepted 7 April
1999
OBJECTIVE
To
investigate the cognitive profile of first degree relatives of patients
with familial Parkinson's disease to determine whether these subjects
presented signs of neuropsychological dysfunction compared with healthy
controls. Results of recent genetic and neuroimaging studies suggest a
genetic contribution to the aetiology of Parkinson's disease and
underline the interest in identifying preclinical signs of the disease.
METHODSA battery of
tests evaluating executive function was administered to 41 first degree
relatives of patients with well documented familial Parkinson's
disease and 39 healthy controls. A factorial discriminant analysis
allowed isolation of a subgroup of 15 first degree relatives who could
be considered as impaired compared with the healthy controls. Among
these 15 "deviant" relatives, nine performed globally worse than
the control subjects on all tasks. The six other subjects had mean or
even high scores on all task variables, except on those highly
correlated with the discriminant score of the factorial discriminant analysis.
RESULTS AND
CONCLUSION Among the first degree relatives of
patients with familial Parkinson's disease, some manifested executive
dysfunction comparable with that typically associated with the disease.
Such impairment could represent a preclinical form of Parkinson's disease.
Keywords: Parkinson's disease; executive function; risk factors
© 1999 by Journal of Neurology, Neurosurgery, and Psychiatry
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