Review
Effect of stimulation of the subthalamic nucleus on oral control
of patients with parkinsonism
Michèle Gentila, Pedro Garcia-Ruizb, Pierre Pollaka, Alim-Louis Benabida
a INSERM,
Unit 318, CHU Grenoble, France, b Department of Neurology,
Fundacion Jimenez-Diaz, Madrid, Spain
Correspondence to: Dr Michèle Gentil, Centre Hospitalier de Grenoble, Clinique Neurologique, BP 217, 738043, France. Telephone 0033 4 76 76 58 52; email michele.Gentil{at}ujf-grenoble.fr
Received 11 December
1998 and in revised form 26 March 1999;
Accepted 7 April
1999
OBJECTIVES
To assess
the oral system of parkinsonian patients treated with
chronic stimulation of the bilateral
subthalamic nucleus (STN) to evaluate precisely the effectiveness of
this procedure on the articulatory organs.
METHODSLoad sensitive
cantilevers were used to sample ramp and hold force contractions
generated by the upper lip, lower lip, and tongue. The subject was
given the instruction to produce forces as rapidly and as accurately as
possible in response to the target signal (ranging from 0.25 to 2 N),
which appeared on a screen. Maximal force of each effector organ was
also measured. Fourteen healthy control subjects and 10 patients
participated in this study. After an overnight fast the patients were
evaluated in the morning under two conditions: during bilateral
stimulation and 1 hour after stopping STN stimulation.
RESULTSDuring STN
stimulation, dynamic and static control of the articulatory organs were
improved: the maximal strength of the articulatory organs, their
accuracy to reach the target, and the precision of the hold phase
increased. In addition, the reaction time and the rise time of the ramp
phase decreased. Patients' speech as assessed by the item 18 of the
unified Parkinson's disease rating scale (UPDRS) was greatly improved
by electrical stimulation of the STN
CONCLUSIONSImprovement
of oral control of the stimulated patients suggests that STN
stimulation modulates neuronal structures involved in speech. However,
more patients have to be evaluated for a fuller understanding of the
effect of this surgical procedure on speech.
Keywords: parkinsonism; surgical therapy; subthalamic nucleus; oral control (speech)
© 1999 by Journal of Neurology, Neurosurgery, and Psychiatry
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Chu, S.-Y., Barlow, S. M., Lee, J.
(2009). Nonparticipatory Stiffness in the Male Perioral Complex. JSLHR
52: 1353-1359
[Abstract] [Full Text] -
Narayana, S., Jacks, A., Robin, D. A., Poizner, H., Zhang, W., Franklin, C., Liotti, M., Vogel, D., Fox, P. T.
(2009). A Noninvasive Imaging Approach to Understanding Speech Changes Following Deep Brain Stimulation in Parkinson's Disease. AJSLP
18: 146-161
[Abstract] [Full Text] -
Klostermann, F, Ehlen, F, Vesper, J, Nubel, K, Gross, M, Marzinzik, F, Curio, G, Sappok, T
(2008). Effects of subthalamic deep brain stimulation on dysarthrophonia in Parkinson's disease. J. Neurol. Neurosurg. Psychiatry
79: 522-529
[Abstract] [Full Text] -
Fraix, V, Pollak, P, Moro, E, Chabardes, S, Xie, J, Ardouin, C, Benabid, A L
(2005). Subthalamic nucleus stimulation in tremor dominant parkinsonian patients with previous thalamic surgery. J. Neurol. Neurosurg. Psychiatry
76: 246-248
[Abstract] [Full Text] -
Pinto, S., Thobois, S., Costes, N., Le Bars, D., Benabid, A.-L., Broussolle, E., Pollak, P., Gentil, M.
(2004). Subthalamic nucleus stimulation and dysarthria in Parkinson's disease: a PET study. Brain
127: 602-615
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
