J Neurol Neurosurg Psychiatry 2000;69:528-530 ( October )

Short report

Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging Stephen E Rose^a, Fang Chen^a, Jonathan B Chalk^b, Fernando O Zelaya^d, Wendy E Strugnell^c, Mark Benson^c, James Semple^e, David M Doddrell^a

^a Centre for Magnetic Resonance, University of Queensland, Brisbane 4072, Australia, ^b Department of Medicine, ^c Department of Radiology, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia, ^d Institute of Psychiatry, DeCrespigny Park, London, SE5 8AF, UK, ^e SmithKline Beecham Pharmaceuticals, Addenbrooke's Centre for Clinical Investigation, Academic Department of Psychiatry, University of Cambridge, Cambridge, CB2 2GG, UK

Correspondence to: Dr Stephen Rose Stephen.Rose{at}cmr.uq.edu.au

Received 23 September 1999 and in revised form 5 April 2000; Accepted 21 May 2000

A NOVEL MRI METHODdiffusion tensor imagingwas used to compare the integrity of several white matter fibre tracts in patients with probable Alzheimer's disease. Relative to normal controls, patients with probable Alzheimer's disease showed a highly significant reduction in the integrity of the association white matter fibre tracts, such as the splenium of the corpus callosum, superior longitudinal fasciculus, and cingulum. By contrast, pyramidal tract integrity seemed unchanged. This novel finding is consistent with the clinical presentation of probable Alzheimer's disease, in which global cognitive decline is a more prominent feature than motor disturbance.


Keywords: Alzheimer's disease; diffusion tensor MRI

---

© 2000 by Journal of Neurology, Neurosurgery, and Psychiatry
CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Fouquet, M., Desgranges, B., Landeau, B., Duchesnay, E., Mezenge, F., de la Sayette, V., Viader, F., Baron, J.-C., Eustache, F., Chetelat, G. (2009). Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease. Brain 0: awp132v1-awp132 [Abstract] [Full Text]  
• Zhang, Y., Schuff, N., Du, A.-T., Rosen, H. J., Kramer, J. H., Gorno-Tempini, M. L., Miller, B. L., Weiner, M. W. (2009). White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI. Brain 0: awp071v1-awp071 [Abstract] [Full Text]  
• Falzone, T. L., Stokin, G. B., Lillo, C., Rodrigues, E. M., Westerman, E. L., Williams, D. S., Goldstein, L. S. B. (2009). Axonal Stress Kinase Activation and Tau Misbehavior Induced by Kinesin-1 Transport Defects. J. Neurosci. 29: 5758-5767 [Abstract] [Full Text]  
• Wang, L., Goldstein, F.C., Veledar, E., Levey, A.I., Lah, J.J., Meltzer, C.C., Holder, C.A., Mao, H. (2009). Alterations in Cortical Thickness and White Matter Integrity in Mild Cognitive Impairment Measured by Whole-Brain Cortical Thickness Mapping and Diffusion Tensor Imaging. Am. J. Neuroradiol. 30: 893-899 [Abstract] [Full Text]  
• Villain, N., Desgranges, B., Viader, F., de la Sayette, V., Mezenge, F., Landeau, B., Baron, J.-C., Eustache, F., Chetelat, G. (2008). Relationships between Hippocampal Atrophy, White Matter Disruption, and Gray Matter Hypometabolism in Alzheimer's Disease. J. Neurosci. 28: 6174-6181 [Abstract] [Full Text]  
• B. Parente, D., Gasparetto, E. L., Cruz, L. C. H. d. Jr., Domingues, R. C., Baptista, A. C., Carvalho, A. C. P., Domingues, R. C. (2008). Potential Role of Diffusion Tensor MRI in the Differential Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease. Am. J. Roentgenol. 190: 1369-1374 [Abstract] [Full Text]  
• He, Y., Chen, Z., Evans, A. (2008). Structural Insights into Aberrant Topological Patterns of Large-Scale Cortical Networks in Alzheimer's Disease. J. Neurosci. 28: 4756-4766 [Abstract] [Full Text]  
• Huang, J., Friedland, R.P., Auchus, A.P. (2007). Diffusion Tensor Imaging of Normal-Appearing White Matter in Mild Cognitive Impairment and Early Alzheimer Disease: Preliminary Evidence of Axonal Degeneration in the Temporal Lobe. Am. J. Neuroradiol. 28: 1943-1948 [Abstract] [Full Text]  
• Nucifora, P. G. P., Verma, R., Lee, S.-K., Melhem, E. R. (2007). Diffusion-Tensor MR Imaging and Tractography: Exploring Brain Microstructure and Connectivity. Radiology 245: 367-384 [Abstract] [Full Text]  
• Sydykova, D., Stahl, R., Dietrich, O., Ewers, M., Reiser, M. F., Schoenberg, S. O., Moller, H.-J., Hampel, H., Teipel, S. J. (2007). Fiber Connections between the Cerebral Cortex and the Corpus Callosum in Alzheimer's Disease: A Diffusion Tensor Imaging and Voxel-Based Morphometry Study. Cereb Cortex 17: 2276-2282 [Abstract] [Full Text]  
• Stahl, R., Dietrich, O., Teipel, S. J., Hampel, H., Reiser, M. F., Schoenberg, S. O. (2007). White Matter Damage in Alzheimer Disease and Mild Cognitive Impairment: Assessment with Diffusion-Tensor MR Imaging and Parallel Imaging Techniques. Radiology 243: 483-492 [Abstract] [Full Text]  
• Zhang, Y., Schuff, N., Jahng, G. -H., Bayne, W., Mori, S., Schad, L., Mueller, S., Du, A. -T., Kramer, J. H., Yaffe, K., Chui, H., Jagust, W. J., Miller, B. L., Weiner, M. W. (2007). Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease. Neurology 68: 13-19 [Abstract] [Full Text]  
• Alsop, D. C., Fearing, M. A., Johnson, K., Sperling, R., Fong, T. G., Inouye, S. K. (2006). Review Article: The Role of Neuroimaging in Elucidating Delirium Pathophysiology. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 61: 1287-1293 [Abstract] [Full Text]  
• Mapstone, M., Logan, D., Duffy, C. J. (2006). Cue integration for the perception and control of self-movement in ageing and Alzheimer's disease.. Brain 129: 2931-2944 [Abstract] [Full Text]  
• Ramani, A., Jensen, J. H., Helpern, J. A. (2006). Quantitative MR Imaging in Alzheimer Disease. Radiology 241: 26-44 [Abstract] [Full Text]  
• Rose, S E, McMahon, K L, Janke, A L, O'Dowd, B, de Zubicaray, G, Strudwick, M W, Chalk, J B (2006). Diffusion indices on magnetic resonance imaging and neuropsychological performance in amnestic mild cognitive impairment. J. Neurol. Neurosurg. Psychiatry 77: 1122-1128 [Abstract] [Full Text]  
• Ray, K. M., Wang, H., Chu, Y., Chen, Y.-F., Bert, A., Hasso, A. N., Su, M.-Y. (2006). Mild Cognitive Impairment: Apparent Diffusion Coefficient in Regional Gray Matter and White Matter Structures. Radiology 241: 197-205 [Abstract] [Full Text]  
• Xie, S., Xiao, J. X., Gong, G. L., Zang, Y. F., Wang, Y. H., Wu, H. K., Jiang, X. X. (2006). Voxel-based detection of white matter abnormalities in mild Alzheimer disease. Neurology 66: 1845-1849 [Abstract] [Full Text]  
• Bokde, A. L. W., Lopez-Bayo, P., Meindl, T., Pechler, S., Born, C., Faltraco, F., Teipel, S. J., Moller, H.-J., Hampel, H. (2006). Functional connectivity of the fusiform gyrus during a face-matching task in subjects with mild cognitive impairment. Brain 129: 1113-1124 [Abstract] [Full Text]  
• Persson, J., Lind, J., Larsson, A., Ingvar, M., Cruts, M., Van Broeckhoven, C., Adolfsson, R., Nilsson, L. -G., Nyberg, L. (2006). Altered brain white matter integrity in healthy carriers of the APOE {varepsilon}4 allele: A risk for AD?. Neurology 66: 1029-1033 [Abstract] [Full Text]  
• Tuch, D. S., Salat, D. H., Wisco, J. J., Zaleta, A. K., Hevelone, N. D., Rosas, H. D. (2005). Choice reaction time performance correlates with diffusion anisotropy in white matter pathways supporting visuospatial attention. Proc. Natl. Acad. Sci. USA 102: 12212-12217 [Abstract] [Full Text]  
• Bozzali, M., Falini, A., Cercignani, M., Baglio, F., Farina, E., Alberoni, M., Vezzulli, P., Olivotto, F., Mantovani, F., Shallice, T., Scotti, G., Canal, N., Nemni, R. (2005). Brain tissue damage in dementia with Lewy bodies: an in vivo diffusion tensor MRI study. Brain 128: 1595-1604 [Abstract] [Full Text]  
• Shiraishi, A., Hasegawa, Y., Okada, S., Kimura, K., Sawada, T., Mizusawa, H., Minematsu, K. (2005). Highly Diffusion-Sensitized Tensor Imaging of Unilateral Cerebral Arterial Occlusive Disease. Am. J. Neuroradiol. 26: 1498-1504 [Abstract] [Full Text]  
• Makris, N., Kennedy, D. N., McInerney, S., Sorensen, A. G., Wang, R., Caviness, V. S. Jr, Pandya, D. N. (2005). Segmentation of Subcomponents within the Superior Longitudinal Fascicle in Humans: A Quantitative, In Vivo, DT-MRI Study. Cereb Cortex 15: 854-869 [Abstract] [Full Text]  
• Choi, S. J., Lim, K. O., Monteiro, I., Reisberg, B. (2005). Diffusion Tensor Imaging of Frontal White Matter Microstructure in Early Alzheimer's Disease: A Preliminary Study. J Geriatr Psychiatry Neurol 18: 12-19 [Abstract]  
• Stokin, G. B., Lillo, C., Falzone, T. L., Brusch, R. G., Rockenstein, E., Mount, S. L., Raman, R., Davies, P., Masliah, E., Williams, D. S., Goldstein, L. S. B. (2005). Axonopathy and Transport Deficits Early in the Pathogenesis of Alzheimer's Disease. Science 307: 1282-1288 [Abstract] [Full Text]  
• Symms, M, Jager, H R, Schmierer, K, Yousry, T A (2004). A review of structural magnetic resonance neuroimaging. J. Neurol. Neurosurg. Psychiatry 75: 1235-1244 [Abstract] [Full Text]  
• Mascalchi, M., Lolli, F., Nave, R. D., Tessa, C., Petralli, R., Gavazzi, C., Politi, L. S., Macucci, M., Filippi, M., Piacentini, S. (2004). Huntington Disease: Volumetric, Diffusion-weighted, and Magnetization Transfer MR Imaging of Brain. Radiology 232: 867-873 [Abstract] [Full Text]  
• Molko, N., Cachia, A., Riviere, D., Mangin, J.F., Bruandet, M., LeBihan, D., Cohen, L., Dehaene, S. (2004). Brain Anatomy in Turner Syndrome: Evidence for Impaired Social and Spatial-Numerical Networks. Cereb Cortex 14: 840-850 [Abstract] [Full Text]  
• Head, D., Buckner, R. L., Shimony, J. S., Williams, L. E., Akbudak, E., Conturo, T. E., McAvoy, M., Morris, J. C., Snyder, A. Z. (2004). Differential Vulnerability of Anterior White Matter in Nondemented Aging with Minimal Acceleration in Dementia of the Alzheimer Type: Evidence from Diffusion Tensor Imaging. Cereb Cortex 14: 410-423 [Abstract] [Full Text]  
• Love, S (2004). Contribution of cerebral amyloid angiopathy to Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 75: 1-4 [Full Text]  
• Zhai, G., Lin, W., Wilber, K. P., Gerig, G., Gilmore, J. H. (2003). Comparisons of Regional White Matter Diffusion in Healthy Neonates and Adults Performed with a 3.0-T Head-only MR Imaging Unit. Radiology 229: 673-681 [Abstract] [Full Text]  
• Good, C. D (2003). Dementia and ageing: Imaging in clinical neuroscience. Br Med Bull 65: 159-168 [Abstract] [Full Text]  
• Petrella, J. R., Coleman, R. E., Doraiswamy, P. M. (2003). Neuroimaging and Early Diagnosis of Alzheimer Disease: A Look to the Future. Radiology 226: 315-336 [Abstract] [Full Text]  
• Molko, N., Pappata, S., Mangin, J.-F., Poupon, F., LeBihan, D., Bousser, M.-G., Chabriat, H. (2002). Monitoring Disease Progression in CADASIL With Diffusion Magnetic Resonance Imaging: A Study With Whole Brain Histogram Analysis. Stroke 33: 2902-2908 [Abstract] [Full Text]  
• Harrison, P. J. (2002). The neuropathology of primary mood disorder. Brain 125: 1428-1449 [Abstract] [Full Text]  
• Bozzali, M, Falini, A, Franceschi, M, Cercignani, M, Zuffi, M, Scotti, G, Comi, G, Filippi, M (2002). White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging. J. Neurol. Neurosurg. Psychiatry 72: 742-746 [Abstract] [Full Text]  
• Albayram, S., Melhem, E. R., Mori, S., Zinreich, S. J., Barkovich, A. J., Kinsman, S. L. (2002). Holoprosencephaly in Children: Diffusion Tensor MR Imaging of White Matter Tracts of the Brainstem—Initial Experience. Radiology 223: 645-651 [Abstract] [Full Text]  
• Filippi, M., Grossman, R. I. (2002). MRI techniques to monitor MS evolution: The present and the future. Neurology 58: 1147-1153 [Abstract] [Full Text]  
• Schocke, M.F.H., Seppi, K., Esterhammer, R., Kremser, C., Jaschke, W., Poewe, W., Wenning, G. K. (2002). Diffusion-weighted MRI differentiates the Parkinson variant of multiple system atrophy from PD. Neurology 58: 575-580 [Abstract] [Full Text]  
• Taber, K. H., Pierpaoli, C., Rose, S. E., Rugg-Gunn, F. J., Chalk, J. B., Jones, D. K., Hurley, R. A. (2002). The Future for Diffusion Tensor Imaging in Neuropsychiatry. J. Neuropsychiatry Clin. Neurosi. 14: 1-5 [Full Text]  
• Melhem, E. R., Mori, S., Mukundan, G., Kraut, M. A., Pomper, M. G., van Zijl, P. C. M. (2002). Diffusion Tensor MR Imaging of the Brain and White Matter Tractography. Am. J. Roentgenol. 178: 3-16 [Full Text]