Short report
Increased plasma neurotensin concentrations in patients with
Parkinson's disease
R-M Schimpffa c, C Avarda, G Fénelond, A-M Lhiaubeta, L Tennezéa, M Vidailhetb, W Rostènea
a INSERM U 339, Hôpital Saint Antoine, 184 rue du Faubourg, St Antoine, 75012 Paris,
France, b Service
de Neurologie, c INSERM U 515, d Service
de Neurologie Hôpital Tenon, 75020 Paris, France
Correspondence to: Dr W Rostene rostene{at}adr.st-antoine.inserm.fr
Received 13 July
2000 and in revised form 13 December 2000;
Accepted 5 January 2001
Plasma neurotensin (NT) was measured by radioimmunoassay in
propanol extracted and unextracted plasma from 16 parkinsonian patients
(four before treatment) and 16 age and sex matched controls. Mean
plasma NT concentrations were consistently higher in parkinsonian patients than in controls and higher in the four untreated patients than in levodopa treated patients suggesting that plasma NT measurement may represent an easy detectable additional index in diagnosing parkinsonism and provides a novel approach to research in this field.
Keywords: Parkinson's disease; plasma neurotensin; dopamine
© 2001 by Journal of Neurology, Neurosurgery, and Psychiatry
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