Short report
Range of cross reactivity of anti-GM1 IgG antibody in
Guillain-Barré syndrome
M Koga, M Tatsumoto, N Yuki, K Hirata
From the
Department of Neurology, Dokkyo University School of Medicine,
Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321-0293,
Japan
Correspondence to: Dr N Yuki yuki{at}dokkyomed.ac.jp
Received 19 October
2000 and in revised form 1 March 2001;
Accepted 6 March
2001
The cross reactivity of anti-GM1 IgG antibody with
various gangliosides and asialo-GM1 in serum samples from 27 patients
with Guillain-Barré syndrome was investigated. An enzyme linked
immunosorbent assay (ELISA) absorption study showed that anti-GM1 IgG
antibody cross reacted with asialo-GM1 in 52% of the patients, GM1b in 41%, GD1b in 22%, and GalNAc-GD1a in 19%, and that it did not cross
react with GM2, GT1b, or GQ1b. The antibody that cross reacted with
GD1b was associated with a high frequency of cranial nerve involvement
and negative Campylobacter jejuni serology.
Anti-GM1 IgG antibody has a broad range of cross reactivity which may
contribute to various clinical variations of Guillain-Barré syndrome.
Keywords: Guillain-Barré syndrome; anti-GM1 antibody; cross reactivity
© 2001 by Journal of Neurology, Neurosurgery, and Psychiatry
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This article has been cited by other articles:
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Koga, M, Yoshino, H, Morimatsu, M, Yuki, N
(2002). Anti-GT1a IgG in Guillain-Barre syndrome. J. Neurol. Neurosurg. Psychiatry
72: 767-771
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