| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
a Sao Paulo Headache
Center, R Maestro Cardim, 887 01323-001, Sao Paulo SP, Brazil, b Jefferson Headache Center, Thomas
Jefferson University Hospital, Philadelphia PA, USA, c Federal
University of Sao Paulo, Brazil, d Universidade de Sao Paulo
Instituto des
Ciencias Biomedicas, e Hospital Israelita Albert Einstein
Correspondence to: Dr M F P Peres, Sao Paulo Headache Center, R Maestro Cardim, 887 01323-001, Sao Paulo SP, Brazil marioperes{at}yahoo.com
Received 29 December
2000 and in revised form 1 May 2001;
Accepted 20 July
2001
OBJECTIVESChronic
migraine (CM), previously called transformed migraine, is a frequent
headache disorder that affects 2%-3% of the general population.
Analgesic overuse, insomnia, depression, and anxiety are disorders that
are often comorbid with CM. Hypothalamic dysfunction has been
implicated in its pathogenesis, but it has never been studied in
patients with CM. The aim was to analyze hypothalamic involvement in CM
by measurement of melatonin, prolactin, growth hormone, and cortisol
nocturnal secretion.
METHODSA total of 338 blood samples (13/patient) from 17 patients with CM and nine age and
sex matched healthy volunteers were taken. Melatonin, prolactin, growth
hormone, and cortisol concentrations were determined every hour for 12 hours. The presence of comorbid disorders was also evaluated.
RESULTSAn abnormal
pattern of hypothalamic hormonal secretion was found in CM. This
included: (1) a decreased nocturnal prolactin peak, (2) increased
cortisol concentrations, (3) a delayed nocturnal melatonin peak in
patients with CM, and (4) lower melatonin concentrations in patients
with CM with insomnia. Growth hormone secretion did not differ from controls.
CONCLUSIONThese
results support hypothalamic involvement in CM, shown by a
chronobiologic dysregulation, and a possible hyperdopaminergic state in
patients with CM. Insomnia might be an important variable in the study findings.
This article has been cited by other articles:
|
|
 |
|
  S-J Wang, J-F Lirng, J-L Fuh, and J-J Chen Reduction in hypothalamic 1H-MRS metabolite ratios in patients with cluster headache J. Neurol. Neurosurg. Psychiatry, May 1, 2006; 77(5): 622 - 625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Holland, S. Akerman, and P. J. Goadsby Orexin 1 Receptor Activation Attenuates Neurogenic Dural Vasodilation in an Animal Model of Trigeminovascular Nociception J. Pharmacol. Exp. Ther., December 1, 2005; 315(3): 1380 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M F P Peres, M A Stiles, H C Siow, and S D Silberstein Excessive daytime sleepiness in migraine patients J. Neurol. Neurosurg. Psychiatry, October 1, 2005; 76(10): 1467 - 1468. [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Levy, M. S. Matharu, K. Meeran, M. Powell, and P. J. Goadsby The clinical characteristics of headache in patients with pituitary tumours Brain, August 1, 2005; 128(8): 1921 - 1930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F.P. Peres, E. Zukerman, F. da Cunha Tanuri, F. R. Moreira, and J. Cipolla-Neto Melatonin, 3 mg, is effective for migraine prevention Neurology, August 24, 2004; 63(4): 757 - 757. [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Levy, H. R. Jager, M. Powell, M. S. Matharu, K. Meeran, and P. J. Goadsby Pituitary Volume and Headache: Size Is Not Everything Arch Neurol, May 1, 2004; 61(5): 721 - 725. [Abstract] [Full Text] [PDF]
|
|
Read all eLetters
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
