Magnetisation transfer ratio analysis of normal appearing white matter in patients with familial and sporadic multiple sclerosis
M Siger-Zajdel, K Selmaj
Department of
Neurology, Medical Academy of Lodz, Poland
Correspondence to: Krzysztof Selmaj MD, PhD, Department of Neurology Medical Academy of Lodz, 22 Kopciñskiego Street, Lodz, Poland kselmaj{at}afazja.am.lodz.pl
Received 12 June 2000 and in revised form 19 June 2001;
Accepted 26 June 2001
OBJECTIVES
To assess
differences in magnetisation transfer ratio (MTR) analysis of normal
appearing white matter (NAWM) in patients with familial multiple
sclerosis (MS) and those with sporadic MS.
METHODS10 patients
with familial MS, 10 patients with sporadic MS, and 10 healthy subjects
were included in the study. Groups were matched according to the sex,
age, disease duration, type of disease, EDSS, and MRI T1 and T2 lesion
load. Magnetisation transfer imaging (MTI) with and without saturation
pulse were performed. On the MTR map 16 different regions of interest
of normal appearing white matter were analyzed.
RESULTSThe mean MTR
value of normal appearing white matter was significantly lower both in
familial patients and those with sporadic MS compared with healthy
subjects (33.8% v 46.4%; 38.6%
v 46.4% respectively, p< 0.05).
Additionally, patients with familial MS showed significantly lower mean
MTR value than patients with sporadic MS (33.8%
v 38.6%, p<0.05). There was also
significant regional varation of MTR values between these two groups of patients.
CONCLUSIONSLower and
more widespread MTR abnormalities in patients with familial MS might
indicate differences in the extent and nature of white matter pathology
between familial and sporadic MS.
Keywords: familial multiple sclerosis; magnetic resonance imaging; magnetisation transfer ratio
© 2001 by Journal of Neurology, Neurosurgery, and Psychiatry
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