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PAPER |
1 Memory Disorders Unit, Department of Neurology, Brigham and Women’s Hospital, Boston, Massachusetts, USA
2 NMR Center, Massachusetts General Hospital, Boston
3 Gerontology Research Unit, Department of Psychiatry, Massachusetts General Hospital, Boston
4 Department of Psychology, Harvard University, Cambridge, Massachusetts
Correspondence to:
Correspondence to:
Dr Reisa Sperling, 221 Longwood Avenue, Boston, MA 02115, USA;
reisa{at}rics.bwh.harvard.edu
Methods: 10 young controls, 10 elderly controls, and seven patients with mild Alzheimer’s disease were studied using fMRI during a face–name association encoding task. The fMRI paradigm used a block design with three conditions: novel face–name pairs, repeated face–name pairs, and visual fixation.
Results: The young and elderly controls differed primarily in the pattern of activation seen in prefrontal and parietal cortices: elderly controls showed significantly less activation in both superior and inferior prefrontal cortices but greater activation in parietal regions than younger controls during the encoding of novel face–name pairs. Compared with elderly controls, the Alzheimer patients showed significantly less activation in the hippocampal formation but greater activation in the medial parietal and posterior cingulate regions.
Conclusions: The pattern of fMRI activation during the encoding of novel associations is differentially altered in the early stages of Alzheimer’s disease compared with normal aging.
Keywords: functional magnetic resonance imaging; Alzheimer’s disease; aging; memory
Abbreviations: fMRI, functional magnetic resonance imaging; MR, magnetic resonance; NINCDS-ADRDA, National Institute of Neurological and Communicative Disorders and Stroke; Alzheimer’s Disease and Related Disorders Association; NvF, novel v fixation; NvR, novel v repeated; RvF, repeated v fixation
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