© 2003 BMJ Publishing Group
SHORT REPORT
ß endorphin concentrations in PBMC of patients with different clinical phenotypes of multiple sclerosis
1 Department of Neuroscience, San Raffaele Hospital, Milan, Italy
2 Department of Pharmacology, University of Milan, Milan, Italy
Correspondence to:
Correspondence to:
Dr M Gironi, San Raffaele, DIMER, Via Olgettina 48, 20132, Milan, Italy;
mgironi{at}dongnocchi.it
The possible link between the opioid peptide ß endorphin and the heterogeneity of the clinical course of multiple sclerosis (MS) was investigated. Peripheral blood mononuclear cells (PBMC) concentrations of ß endorphin were measured in 50 patients in different phases of MS. Thirty nine patients also underwent post-contrast magnetic resonance imaging of the brain. Among MS forms, the highest ß endorphin concentrations were found in PBMC from patients with relapsing remitting MS and the lowest in patients with the progressive forms. Average ß endorphin concentrations were lower, although not significantly, in patients with than in those without magnetic resonance imaging enhanced lesions. These data suggest that ß endorphin may have a role in the downregulation of the inflammatory process.
Keywords: ß endorphin; multiple sclerosis; immunomodulation
Abbreviations: MS, multiple sclerosis; PBMC, peripheral blood mononuclear cells
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