HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Erratum Submit a response Read responses to this article Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kelkar, P Articles by Parry, G J Search for Related Content PubMed PubMed Citation Articles by Kelkar, P Articles by Parry, G J

Mononeuritis multiplex in diabetes mellitus: evidence for underlying immune pathogenesis

¹ Department of Neurology, University of Iowa, Iowa City, Iowa, USA
² Department of Neurology, University of Minnesota, Minneapolis, Minnesota, USA

Correspondence to:
Correspondence to:
Dr Praful Kelkar, Department of Neurology 2RCP, University of Iowa Hospitals, 200 Hawkins Drive, Iowa City, IA 52242, USA;
praful-kelkar{at}uiowa.edu

ABSTRACT
Four patients with type 2 diabetes mellitus developed mononeuritis multiplex subacutely. Sural nerve biopsies showed multifocal axonal loss in all patients, with epineurial perivascular inflammation affecting small calibre vessels in three. Three patients improved with immunotherapy. These observations suggest that mononeuritis multiplex in diabetes may be caused by an immune mediated vasculopathy and that it is pathogenetically akin to the more common and better recognised diabetic amyotrophy.

Keywords: diabetic neuropathy; mononeuritis multiplex; inflammatory neuropathy

eLetters: