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Apolipoprotein E genotypes and clinical outcome in Guillain-Barré syndrome

¹ Department of Clinical Neurosciences, Guy’s, King’s and St Thomas’ School of Medicine, London SE1, UK
² The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1
³ Division of Clinical Neurosciences, University of Glasgow, Southern General Hospital, Glasgow, UK
⁴ Division of Clinical Neurosciences, University of Southampton, Southampton General Hospital, Southampton, UK

Correspondence to:
Correspondence to:
Dr Jane Pritchard, Department of Clinical Neurosciences, Guy’s, King’s and St Thomas’ School of Medicine, Guy’s Hospital, Hodgkin Building, London SE1 1UL, UK;
jane.pritchard{at}kcl.ac.uk

Objective: To correlate APOE genotypes with residual disability and degree of improvement in Guillain-Barré syndrome, assessed one year after presentation

Methods: 91 patients with the syndrome were recruited from southeast England and their APOE genotypes were determined.

Results: There were no clear differences in APOE genotype or allele frequencies when comparing the 91 patients with controls, nor when comparing 81 patients with good outcome and 10 with poor outcome.

Conclusions: APOE genotype did not influence susceptibility to Guillain-Barré syndrome or recovery from it. This may be because our sample size of 91 was not sufficiently large to detect small differences in recovery associated with different APOE genotypes, or because cholesterol transportation is not a crucial rate limiting step in peripheral nerve regeneration.

Keywords: apolipoprotein E; Guillain-Barré syndrome; neuropathy

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