JNNP

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
[Advanced]

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Oh, J
Right arrow Articles by Pelletier, D
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oh, J
Right arrow Articles by Pelletier, D
Journal of Neurology Neurosurgery and Psychiatry 2004;75:1281-1286
© 2004 BMJ Publishing Group Ltd


PAPER

Mechanisms of normal appearing corpus callosum injury related to pericallosal T1 lesions in multiple sclerosis using directional diffusion tensor and 1H MRS imaging

J Oh1, R G Henry1, C Genain2, S J Nelson1, D Pelletier2

1 Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, CA, USA
2 UCSF Multiple Sclerosis Center, Department of Neurology, University of California, San Francisco, CA, USA

Correspondence to:
Correspondence to:
Dr J Oh
Magnetic Resonance Science Center, Department of Radiology, Box 0946, University of California, San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94107, USA; joonmi{at}mrsc.ucsf.edu

Objectives: To investigate the extent of tissue damage in a region of normal appearing corpus callosum (NACC) for different forms of multiple sclerosis (MS) using diffusion tensor and proton magnetic resonance (MR) spectroscopic imaging.

Methods: A total of 47 patients with MS and 15 controls were included. Regions of interest from the NACC were manually segmented using high resolution anatomical images. Diffusion tensor eigenvalues and metabolite ratio of N-acetyl-aspartate (NAA) to creatine/phosphocreatine (Cr) were calculated in the NACC region.

Results: Increased apparent diffusion coefficients (ADCs) and decreased anisotropy were observed in the NACC for patients with MS relative to the control subjects. These resulted from increased diffusion tensor eigenvalues perpendicular to the maximum diffusion direction. The NAA:Cr ratio was decreased in the NACC for patients with MS relative to the control subjects. Significant correlations between pericallosal T1 lesion load and MR modalities in the NACC were observed for patients with relapsing remitting/secondary progressive MS (RR/SPMS), but not for patients with primary progressive MS (PPMS).

Conclusion: This study provides further insight into changes in the ADC and diffusion anisotropy based on the diffusion tensor eigenvalues for patients with MS. The changes in the diffusion tensor eigenvalues and NAA:Cr ratio in the NACC for patients with RR/SPMS suggest axonal injury and/or dysfunction induced by wallerian degeneration. The lack of correlation between these variables in the NACC and focal MS lesions for patients with PPMS further supports intrinsic differences related to tissue injury between these subtypes of MS.


Abbreviations: ADC, apparent diffusion coefficient; 3D SPGR, three dimensional spoiled gradient echo; CSF, cerebrospinal fluid; Cr, creatine/phosphocreatine; EDSS, Expanded Disability Status Scale; FLAIR, fluid attenuated inversion recovery; 1H MRSI, proton magnetic resonance spectroscopic imaging; MS, multiple sclerosis; NAA, N-acetyl-aspartate; NAWM, normal appearing white matter; PPMS, primary progressive MS; SPMS, secondary progressive MS; ROI, region of interest; RRMS, relapsing remitting MS

Keywords: diffusion tensor eigenvalues; 1H MRSI; corpus callosum; wallerian degeneration; multiple sclerosis




This article has been cited by other articles:


Home page
J. Neurosci.Home page
L. Bonzano, A. Tacchino, L. Roccatagliata, G. Abbruzzese, G. L. Mancardi, and M. Bove
Callosal Contributions to Simultaneous Bimanual Finger Movements
J. Neurosci., March 19, 2008; 28(12): 3227 - 3233.
[Abstract] [Full Text] [PDF]


Home page
NeurologyHome page
M. A. Rocca, E. Pagani, M. Absinta, P. Valsasina, A. Falini, G. Scotti, G. Comi, and M. Filippi
Altered functional and structural connectivities in patients with MS: A 3-T study
Neurology, December 4, 2007; 69(23): 2136 - 2145.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Neuroradiol.Home page
F. Lin, C. Yu, T. Jiang, K. Li, and P. Chan
Diffusion Tensor Tractography-Based Group Mapping of the Pyramidal Tract in Relapsing-Remitting Multiple Sclerosis Patients
AJNR Am. J. Neuroradiol., February 1, 2007; 28(2): 278 - 282.
[Abstract] [Full Text] [PDF]


Home page
Mult SclerHome page
B Audoin, D Ibarrola, I Malikova, E Soulier, S Confort-Gouny, M-V A. Duong, F Reuter, P Viout, A Ali-Cherif, P J Cozzone, et al.
Onset and underpinnings of white matter atrophy at the very early stage of multiple sclerosis - a two-year longitudinal MRI/MRSI study of corpus callosum
Multiple Sclerosis, January 1, 2007; 13(1): 41 - 51.
[Abstract] [PDF]


Home page
Am. J. Neuroradiol.Home page
H. Ni, V. Kavcic, T. Zhu, S. Ekholm, and J. Zhong
Effects of number of diffusion gradient directions on derived diffusion tensor imaging indices in human brain.
AJNR Am. J. Neuroradiol., September 1, 2006; 27(8): 1776 - 1781.
[Abstract] [Full Text] [PDF]


Home page
Arch NeurolHome page
J. Imitola, T. Chitnis, and S. J. Khoury
Insights Into the Molecular Pathogenesis of Progression in Multiple Sclerosis: Potential Implications for Future Therapies
Arch Neurol, January 1, 2006; 63(1): 25 - 33.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2004 by the BMJ Publishing Group Ltd.