| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
PAPER |
1 Department of Neurology, Kuopio University Hospital, Kuopio, Finland
2 Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland
3 Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
4 Department of Public Health, University of Kuopio, Kuopio, Finland
5 The National Institute of Public Health, Helsinki, Finland
6 The Laboratory of Epidemiology & Neuroimaging, IRCCS San Giovanni di Dio-FBF, Brescia, Italy
7 AFaR- Associazione Fatebenefratelli per la Ricerca, Rome, Italy
8 The Machine Vision Laboratory, Department of Mathematics and Computer Science, University of Udine, Udine, Italy
Correspondence to:
Correspondence to:
Dr H Soininen
Department of Neurology, Bldg. 5, Kuopio University Hospital, POB 1777, 70211 Kuopio, Finland; hilkka.soininen{at}kuh.fi
Background: Mild cognitive impairment (MCI) is the most widely used concept in classifying cognitive impairment in the elderly who do not fulfil the criteria for dementia. MCI is considered to confer an increased risk of progressing to dementia and most often Alzheimer’s disease (AD). Various approaches such as imaging of the brain have been applied to predict the conversion of MCI to dementia. A number of volumetric magnetic resonance imaging (MRI) studies have detected atrophy of the medial temporal lobe in subjects with MCI, but for the other cerebral regions the results have been inconsistent.
Objective: To study the pattern of brain atrophy in MCI.
Methods: Thirty two controls and 51 individuals with MCI deriving from population based cohorts were studied by MRI using voxel based morphometry. The threshold of t maps was set at p<0.001.
Results: Individuals with MCI had significant unilateral atrophy in the medial temporal lobe on the right side. Less extensive atrophy was found elsewhere—for example, in the temporal lobe, left superior parietal lobule, left anterior cingulate gyrus, and bilaterally in the thalami.
Conclusions: The MRI findings in MCI resemble those seen in early AD.
Abbreviations: AD, Alzheimer’s disease; CDR, clinical dementia rating; CSF, cerebrospinal fluid; GM, grey matter; HERA, hemispheric encoding/retrieval asymmetry; MCI, mild cognitive impairment; MRI, magnetic resonance imaging; VBM, voxel based morphometry; WM, white matter
Keywords: MRI; mild cognitive impairment; voxel based method
This article has been cited by other articles:
|
|
 |
|
  G. Karas, J. Sluimer, R. Goekoop, W. van der Flier, S.A.R.B. Rombouts, H. Vrenken, P. Scheltens, N. Fox, and F. Barkhof Amnestic Mild Cognitive Impairment: Structural MR Imaging Findings Predictive of Conversion to Alzheimer Disease AJNR Am. J. Neuroradiol., May 1, 2008; 29(5): 944 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Whitwell, M. M. Shiung, S. A. Przybelski, S. D. Weigand, D. S. Knopman, B. F. Boeve, R. C. Petersen, and C. R. Jack Jr MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment Neurology, February 12, 2008; 70(7): 512 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Whitwell, S. A. Przybelski, S. D. Weigand, D. S. Knopman, B. F. Boeve, R. C. Petersen, and C. R. Jack Jr 3D maps from multiple MRI illustrate changing atrophy patterns as subjects progress from mild cognitive impairment to Alzheimer's disease Brain, July 1, 2007; 130(7): 1777 - 1786. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K Beyer, C. C Janvin, J. P Larsen, and D. Aarsland A magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel-based morphometry J. Neurol. Neurosurg. Psychiatry, March 1, 2007; 78(3): 254 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Golob, R. Irimajiri, and A. Starr Auditory cortical activity in amnestic mild cognitive impairment: relationship to subtype and conversion to dementia Brain, March 1, 2007; 130(3): 740 - 752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.M. Mezzapesa, A. Ceccarelli, F. Dicuonzo, A. Carella, M.F. De Caro, M. Lopez, V. Samarelli, P. Livrea, and I.L. Simone Whole-Brain and Regional Brain Atrophy in Amyotrophic Lateral Sclerosis AJNR Am. J. Neuroradiol., February 1, 2007; 28(2): 255 - 259. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S E Rose, K L McMahon, A L Janke, B O'Dowd, G de Zubicaray, M W Strudwick, and J B Chalk Diffusion indices on magnetic resonance imaging and neuropsychological performance in amnestic mild cognitive impairment J. Neurol. Neurosurg. Psychiatry, October 1, 2006; 77(10): 1122 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Saykin, H. A. Wishart, L. A. Rabin, R. B. Santulli, L. A. Flashman, J. D. West, T. L. McHugh, and A. C. Mamourian Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology, September 12, 2006; 67(5): 834 - 842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.K. Sandstrom, S. Krishnan, M.J. Slavin, T.-T.T. Tran, P.M. Doraiswamy, and J.R. Petrella Hippocampal Atrophy Confounds Template-Based Functional MR Imaging Measures of Hippocampal Activation in Patients with Mild Cognitive Impairment. AJNR Am. J. Neuroradiol., September 1, 2006; 27(8): 1622 - 1627. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bozzali, M. Filippi, G. Magnani, M. Cercignani, M. Franceschi, E. Schiatti, S. Castiglioni, R. Mossini, M. Falautano, G. Scotti, et al. The contribution of voxel-based morphometry in staging patients with mild cognitive impairment Neurology, August 8, 2006; 67(3): 453 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Hildebrandt, H K Hahn, J A Kraus, A Schulte-Herbruggen, B Schwarze, and G Schwendemann Memory performance in multiple sclerosis patients correlates with central brain atrophy Multiple Sclerosis, August 1, 2006; 12(4): 428 - 436. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
