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Multiple pathologies in a patient with a progressive neurodegenerative syndrome

¹ Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
² Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine

Correspondence to:
Correspondence to:
Dr Tsao-Wei Liang
Parkinson’s Disease Research, Education, and Clinical Center, Philadelphia VA Medical Center, University and Woodland Avenues, Philadelphia, PA 19104, USA; liangtw{at}mail.med.upenn.edu

ABSTRACT
A woman presenting with levodopa responsive Parkinsonism developed rapidly progressive bulbar signs, quadriparesis, and upper and lower motor neurone signs. At necropsy, she was found to have three pathological diagnoses: amyotrophic lateral sclerosis, Parkinson’s disease, and abundant tau-positive argyrophilic neuritic pathology, known as argyrophilic grain disease. This case raises the possibility that three distinct neuropathological diagnoses share a common aetiology.

Abbreviations: AGD, argyrophilic grain disease; ALS, amyotrophic lateral sclerosis; DLB, dementia with Lewy bodies; MSA, multiple system atrophy; PSP, progressive supranuclear palsy

Keywords: -synuclein; amyotrophic lateral sclerosis; progressive neurodegeneration; Parkinson’s disease

This article has been cited by other articles:

				I. Ferrer, G. Santpere, and F. W. van Leeuwen Argyrophilic grain disease Brain, June 1, 2008; 131(6): 1416 - 1432. [Abstract] [Full Text] [PDF]