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Admission blood glucose and short term survival in primary intracerebral haemorrhage: a population based study

¹ Department of Neurology, University of Helsinki, Helsinki, Finland
² Department of Neurology, Jorvi Hospital, Finland
³ Department of Neurology, Central Hospital of Central Finland, Jyväskylä, Finland
⁴ Department of Neurology, Kainuu Central Hospital, Kajaani, Finland

Correspondence to:
Correspondence to:
Dr R Fogelholm
Pappilantie 10 B 8, 02400 Kirkkonummi, Finland; r.fogel{at}kolumbus.fi

Background: The role of admission blood glucose level on the prognosis of patients with intracerebral haemorrhage has not been elucidated.

Objective: To examine this association on the basis of an epidemiologically representative patient material.

Methods: 249 500 people living in the catchment area of the Central Hospital of Central Finland. The diagnosis of ICH was established if verified by cranial computed tomography (CT) or autopsy.

Results: Of the 416 patients who fulfilled the diagnostic criteria, 30 died before admission and 386 were admitted to the Central Hospital. All 329 patients (290 nondiabetics and 39 diabetics) with both admission blood glucose and cranial CT data were included in the study. The mean blood glucose level was 10.6 mmol/l for nondiabetics who died on the day of onset, 8.6 mmol/l for those dying during days 1 to 28, and 6.8 mmol/l for the 28 day survivors. The corresponding figures for diabetics were 13.9 mmol/l, 12.5 mmol/l, and 9.3 mmol/l. In both nondiabetics and diabetics, patients who died had significantly higher mean glucose than the 28 day survivors (p<0.0001 versus p = 0.029). However, blood glucose of the surviving diabetics was as high as that of the deceased nondiabetics (9.3 mmol/l versus 9.1 mmol/l). In nondiabetics, admission blood glucose was associated with parameters signifying severe stroke; disturbed consciousness, large haematoma volume and shift of cerebral midline structures, and high admission mean arterial pressure. In logistic regression analysis, high admission blood glucose in nondiabetics was a significant predictor of death during the first 28 days of onset (odds ratio 1.22, 95% CI 1.07 to 1.40).

Conclusions: High admission blood glucose predicts increased 28 day case fatality rate in both nondiabetic and diabetic patients with ICH. Because high admission blood glucose was associated with markers of severe stroke, we are inclined to support the stress theory; high admission blood glucose is the result of a serious ICH.

Abbreviations: BP, blood pressure; CT, computed tomography; ECG, electrocardiographic; ICH, intracerebral haemorrhage; MAP, mean arterial pressure

Keywords: blood glucose; hyperglycaemia; intracerebral haemorrhage; stress; survival

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