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Cerebellar abnormalities on proton MR spectroscopy in gluten ataxia

¹ Academic Unit of Radiology, University of Sheffield, Sheffield, England
² Department of Neurology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, England

Correspondence to:
Correspondence to:
Dr I D Wilkinson
Academic Unit of Radiology, C Floor, Royal Hallamshire Hospital, Glossop Road, Sheffield S10 2JF, England; i.d.wilkinson{at}shef.ac.uk

ABSTRACT
Gluten sensitivity can manifest with ataxia. The metabolic status of the cerebellum was investigated in 15 patients with gluten ataxia and 10 controls using proton MR spectroscopy. Significant differences were present in mean N-acetyl aspartate levels at short echo time and N-acetyl aspartate/choline ratios at long echo time between the patient and control groups. These data support the hypothesis that cerebellar neuronal physiology differs between patients with gluten ataxia and healthy controls.

Abbreviations: Cho, cholines; Cr, creatines; GLx, glutamate/glutamine; mI, myo-inositol; NAA, N-acetyl aspartate; ppm, parts per million; PRESS, point resolved spin echo technique; STEAM, stimulated echo acquisition mode; TE, time of echo

Keywords: MRS; ataxia; gluten sensitivity; magnetic resonance spectroscopy

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				L.I. Wallis, P.D. Griffiths, S.J. Ritchie, C.A.J. Romanowski, G. Darwent, and I.D. Wilkinson Proton Spectroscopy and Imaging at 3T in Ataxia-Telangiectasia AJNR Am. J. Neuroradiol., January 1, 2007; 28(1): 79 - 83. [Abstract] [Full Text] [PDF]