REVIEW

The effect of deep brain stimulation on quality of life in movement disorders

A Diamond and J Jankovic

Department of Neurology, Baylor College of Medicine, Houston, TX, USA

Correspondence to:
Correspondence to:
Joseph Jankovic
Department of Neurology, Parkinson’s Disease Center and Movement Disorders Clinic, Baylor College of Medicine, 6550 Fannin St, Suite 1801, Houston, TX 77030, USA; josephj{at}bmc.tmc.edu

Deep brain stimulation (DBS) is a viable treatment alternative for patients with Parkinson’s disease (PD), essential tremor (ET), dystonia, and cerebellar outflow tremors. When poorly controlled, these disorders have detrimental effects on the patient’s health related quality of life (HRQoL). Instruments that measure HRQoL are useful tools to assess burden of disease and the impact of therapeutic interventions on activities of daily living, employment, and other functions. We systematically and critically reviewed the literature on the effects of DBS on HRQoL in PD, ET, dystonia, and cerebellar outflow tremor related to multiple sclerosis.

Abbreviations: ADL, activities of daily living; BAI, Beck’s Anxiety Index; BDI, Beck Depression Index; BFMD, Burke-Fahn-Marsden dystonia scale; DBS, deep brain stimulation; ET, essential tremor; GPi, globus pallidus; HRQoL, health related quality of life; MS, multiple sclerosis; NHP, Nottingham Health Profile; PD, Parkinson’s disease; PMS, Profile of Mood State; QUEST, Quality of Life in Essential Tremor Questionnaire; SF-36, Medical Outcomes Study 36-item Short-Form General Health Survey; SIP, Sickness Impact Profile; STN, subthalamic nucleus; TWSTR Scale, Toronto Western Spasmodic Torticollis Rating Scale; Vim, ventral intermediate nucleus of the thalamus

Keywords: deep brain stimulation; dystonia; essential tremor; multiple sclerosis; Parkinson’s disease; quality of life

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