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Effects of sleep deprivation on cortical excitability in patients affected by juvenile myoclonic epilepsy: a combined transcranial magnetic stimulation and EEG study

¹ Dipartimento di Scienze Neurologiche e della Visione, Servizio di Neurologia ad Indirizzo Riabilitativo, University of Verona, Verona, Italy
² Dipartimento di Scienze Neurologiche e della Visione, Sezione di Neurologia, University of Verona, Verona, Italy

Correspondence to:
Correspondence to:
Dr Paolo Manganotti
Dipartimento di Scienze Neurologiche e della Visione, Sezione di Neurologia Riabilitativa, Policlinico Borgo Roma, Via delle Menegone, 37134 Verona, Italy; paolo.manganotti{at}univr.it

Objective: To investigate the effect of sleep deprivation on corticospinal excitability in patients affected by juvenile myoclonic epilepsy (JME) using different transcranial magnetic stimulation (TMS) parameters.

Methods: Ten patients with JME and 10 normal subjects underwent partial sleep deprivation. Motor threshold (MT), motor evoked potential amplitude (MEP), and silent period (SP) were recorded from the thenar eminence (TE) muscles. Short latency intracortical inhibition (SICI) and short latency intracortical facilitation (SICF) were studied using paired magnetic stimulation. TMS was performed before and after sleep deprivation; EEG and TMS were performed simultaneously.

Results: In patients with JME, sleep deprivation induced a significant decrease in SICI and an increase in SICF, which was associated with increased paroxysmal activity. A significant decrease in the MT was observed. No significant changes in any TMS parameters were noted in normal subjects after sleep deprivation. The F wave was unchanged by sleep deprivation in both control subjects and in patients with JME.

Conclusions: In patients with JME, sleep deprivation produces increases in corticospinal excitability in motor areas as measured by different TMS parameters.

Abbreviations: cMAP, compound motor action potential; ISI, interstimulus interval; JME, juvenile myoclonic epilepsy; MEP, motor evoked potential; MT, motor threshold; SICF, short latency intracortical facilitation; SICI, short latency intracortical inhibition; SP, silent period; TE, thenar eminence; TMS, transcranial magnetic stimulation; VAS, visual analogue scale

Keywords: cortex excitability; EEG; epilepsy; sleep; transcranial magnetic stimulation

This article has been cited by other articles:

				C. Civardi, A. Collini, R . Macdonell, A .B. Badawy, J .M. Curatolo, M . Newton, and S .F. Berkovic SLEEP DEPRIVATION INCREASES CORTICAL EXCITABILITY IN EPILEPSY: SYNDROME-SPECIFIC EFFECTS Neurology, July 17, 2007; 69(3): 318 - 319. [Full Text] [PDF]

				R.A.B. Badawy, J. M. Curatolo, M. Newton, S. F. Berkovic, and R. A.L. Macdonell Sleep deprivation increases cortical excitability in epilepsy: Syndrome-specific effects. Neurology, September 26, 2006; 67(6): 1018 - 1022. [Abstract] [Full Text] [PDF]