|
|
||||||||||||||
|
|
|||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SHORT REPORT |
1 Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
2 Biomedical Research Institute August Pi i Sunyer (IDIBAPS), Barcelona
3 Department of Animal Biology, University of Barcelona
4 Department of Neurosurgery, Vall dHebron University Hospital, Barcelona
5 Neurotraumatology Intensive Care Unit, Vall dHebron University Hospital, Barcelona
Correspondence to:
Correspondence to:
Dr M Ariza
Departament de Psiquiatria i Psicobiologia Clínica, Universitat de Barcelona, Passeig de la Vall dHebron, 171, 08035 Barcelona, Spain; marizago7{at}docd4.ub.edu
ABSTRACT
Aim: To analyse the influence of apolipoprotein (APOE)
4 status on the cognitive and behavioural functions usually impaired after moderate and severe traumatic brain injury (TBI).
Methods: In all, 77 patients with TBI selected from 140 consecutive admissions were genotyped for APOE. Each patient was subjected to neuropsychological and neurobehavioural assessment at least 6 months after injury.
Results: Performance of participants carrying the
4 allele was notably worse on verbal memory (Auditory Verbal Learning Test), motor speed, fine motor coordination, visual scanning, attention and mental flexibility (Grooved Pegboard, Symbol Digit Modalities Test and part B of the Trail Making Test) and showed considerably more neurobehavioural disturbances (Neurobehavioral Rating ScaleRevised) than the group without the
4 allele.
Conclusions: In particular, performance on neuropsychological tasks that are presumed to be related to temporal lobe, frontal lobe and white matter integrity is worse in patients with the APOE
4 allele than in those without it. More neurobehavioural disturbances are observed in APOE
4 carriers than in APOE
2 and
3 carriers.
Abbreviations: APOE, apolipoprotein; apoE, apolipoprotein E; GCS, Glasgow Coma Scale; TBI, traumatic brain injury
Relevant Articles
J. Neurol. Neurosurg. Psychiatry 2006 77: 1106-1107.
J. Neurol. Neurosurg. Psychiatry 2006 77: 363-366.
This article has been cited by other articles:
![]() |
V. Raymont, A. Greathouse, K. Reding, R. Lipsky, A. Salazar, and J. Grafman Demographic, structural and genetic predictors of late cognitive decline after penetrating head injury Brain, February 1, 2008; 131(2): 543 - 558. [Abstract] [Full Text] [PDF] |
||||
![]() |
S D. Han, A. I Drake, L. M Cessante, A. J Jak, W. S Houston, D. C Delis, J V. Filoteo, and M. W Bondi Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism? J. Neurol. Neurosurg. Psychiatry, October 1, 2007; 78(10): 1103 - 1108. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Wilson and H. Montgomery Impact of genetic factors on outcome from brain injury Br. J. Anaesth., July 1, 2007; 99(1): 43 - 48. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |