HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) All Versions of this Article: jnnp.2005.085167v1 77/10/1191    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ariza, M Articles by Sahuquillo, J Search for Related Content PubMed PubMed Citation Articles by Ariza, M Articles by Sahuquillo, J Topic Collections Relevant Articles

Influence of APOE polymorphism on cognitive and behavioural outcome in moderate and severe traumatic brain injury

¹ Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
² Biomedical Research Institute August Pi i Sunyer (IDIBAPS), Barcelona
³ Department of Animal Biology, University of Barcelona
⁴ Department of Neurosurgery, Vall d’Hebron University Hospital, Barcelona
⁵ Neurotraumatology Intensive Care Unit, Vall d’Hebron University Hospital, Barcelona

Correspondence to:
Correspondence to:
Dr M Ariza
Departament de Psiquiatria i Psicobiologia Clínica, Universitat de Barcelona, Passeig de la Vall d’Hebron, 171, 08035 Barcelona, Spain; marizago7{at}docd4.ub.edu

ABSTRACT
Aim: To analyse the influence of apolipoprotein (APOE) 4 status on the cognitive and behavioural functions usually impaired after moderate and severe traumatic brain injury (TBI).

Methods: In all, 77 patients with TBI selected from 140 consecutive admissions were genotyped for APOE. Each patient was subjected to neuropsychological and neurobehavioural assessment at least 6 months after injury.

Results: Performance of participants carrying the 4 allele was notably worse on verbal memory (Auditory Verbal Learning Test), motor speed, fine motor coordination, visual scanning, attention and mental flexibility (Grooved Pegboard, Symbol Digit Modalities Test and part B of the Trail Making Test) and showed considerably more neurobehavioural disturbances (Neurobehavioral Rating Scale—Revised) than the group without the 4 allele.

Conclusions: In particular, performance on neuropsychological tasks that are presumed to be related to temporal lobe, frontal lobe and white matter integrity is worse in patients with the APOE 4 allele than in those without it. More neurobehavioural disturbances are observed in APOE 4 carriers than in APOE 2 and 3 carriers.

Abbreviations: APOE, apolipoprotein; apoE, apolipoprotein E; GCS, Glasgow Coma Scale; TBI, traumatic brain injury

Relevant Articles

Apolipoprotein E4 and traumatic brain injury

H Houlden and R Greenwood
J. Neurol. Neurosurg. Psychiatry 2006 77: 1106-1107. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				V. Raymont, A. Greathouse, K. Reding, R. Lipsky, A. Salazar, and J. Grafman Demographic, structural and genetic predictors of late cognitive decline after penetrating head injury Brain, February 1, 2008; 131(2): 543 - 558. [Abstract] [Full Text] [PDF]

				S D. Han, A. I Drake, L. M Cessante, A. J Jak, W. S Houston, D. C Delis, J V. Filoteo, and M. W Bondi Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism? J. Neurol. Neurosurg. Psychiatry, October 1, 2007; 78(10): 1103 - 1108. [Abstract] [Full Text] [PDF]

				M. Wilson and H. Montgomery Impact of genetic factors on outcome from brain injury Br. J. Anaesth., July 1, 2007; 99(1): 43 - 48. [Abstract] [Full Text] [PDF]