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Cardiac ¹²³I-MIBG scintigraphy in patients with drug induced parkinsonism

¹ Department of Neurology, Ajou University School of Medicine, Suwon, South Korea
² Department of Neurology and Nuclear Medicine, Ajou University School of Medicine
³ Department of Neurology, Catholic University of Korea, Seoul

Correspondence to:
Correspondence to:
Dr Phil Hyu Lee
Department of Neurology, College of Medicine Ajou University, Woncheon-dong San 5, Paldal-ku, Suwon, Kyungki-do, 442-749, South Korea; phisland{at}chol.com

ABSTRACT
Cardiac sympathetic dysfunction was investigated using ¹²³I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy in 20 patients with drug induced parkinsonism (DIP). The mean heart to mediastinum ratio was significantly greater in patients with DIP than in those with Parkinson’s disease (mean (SD): 2.07 (0.39) v 1.28 (0.15), p<0.001). MIBG uptake was not different between the DIP patients and controls. Two DIP patients whose MIBG uptake was significantly reduced showed persistent parkinsonism and responded dramatically to levodopa.

Keywords: cardiac MIBG; drug induced parkinsonism

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				P. H. Lee, S. H. Yeo, S. W. Yong, and Y. J. Kim Odour identification test and its relation to cardiac 123I-metaiodobenzylguanidine in patients with drug induced parkinsonism J. Neurol. Neurosurg. Psychiatry, November 1, 2007; 78(11): 1250 - 1252. [Abstract] [Full Text] [PDF]