HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) All Versions of this Article: jnnp.2005.075713v1 77/4/457    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Padovani, A Articles by Perani, D Search for Related Content PubMed PubMed Citation Articles by Padovani, A Articles by Perani, D Related Collections Other Neurology Other imaging techniques

Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy

¹ Department of Medical Sciences, Neurology, University of Brescia, Brescia, Italy
² "Vita-Salute", San Raffaele University, Milan, Italy
³ Scientific Institute San Raffaele, Milan, Italy
⁴ "Ancelle della Carità" Hospital, Cremona, Italy
⁵ IRCCS, Memory Clinic, Alzheimer Centre, Brescia, Italy
⁶ Neuroradiology, University of Brescia, Brescia, Italy
⁷ Vita-Salute San Raffaele University, IRCCS San Raffaele and INB-CNR, Milan

Correspondence to:
Correspondence to:
Dr Alessandro Padovani
Clinica Neurologica, Università degli Studi di Brescia, Pza Spedali Civili, 1-25100 Brescia, Italy; padovani{at}med.unibs.it

Background: A comprehensive characterisation of grey and white matter changes in progressive supranuclear palsy (PSP), the second most common extrapyramidal syndrome after Parkinson disease, is still not available.

Objective: To evaluate grey and white matter changes in mild PSP patients by voxel based morphometry (VBM) and diffusion tensor imaging (DTI), respectively.

Methods: 14 mild PSP patients and 14 healthy controls entered the study and underwent a clinical and neuropsychological evaluation according with a standardised assessment. Each subject had a structural magnetic resonance imaging (MRI) study. Processing analysis of MRI data was carried out according to optimised VBM and fractional anisotropy was determined.

Results: Compared with the controls, in PSP patients VBM analysis showed a significant clusters of reduced grey matter in premotor cortex, frontal operculum, anterior insula, hippocampus, and parahippocampal gyrus, bilaterally. With regard to subcortical brain regions, the pulvinar, dorsomedial and anterior nuclei of the thalamus, and superior and inferior culliculum were affected bilaterally. A bilateral decrease in fractional anisotropy in superior longitudinal fasciculus, anterior part of corpus callosum, arcuate fascicolus, posterior thalamic radiations, and internal capsule, probably involving the cortico-bulbar tracts, was present in PSP patients.

Conclusions: These data provide evidence for both grey and white matter degeneration in PSP from the early disease stage. These structural changes suggest that atrophy of cortical and subcortical structures and neurodegeneration of specific fibre tracts contribute to neurological deficits in PSP.

Abbreviations: BADL, basic activities of daily living; CDR, clinical dementia rating scale; CSF, cerebrospinal fluid; DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, fourth edition; DTI, diffusion tensor imaging; FA, fractional anisotropy; FBI, frontal behavioural inventory; FDR, false discovery rate; FWHM, full width at half maximum; GM, grey matter; IADL, instrumental activities of daily living; MMSE, mini-mental state examination; MNI, Montreal Neurological Institute; NPI, neuropsychiatric inventory; PSP, progressive supranuclear palsy; UPDRS, unified Parkinson disease rating scale; VBM, voxel based morphometry; WM, white matter

Keywords: progressive supranuclear palsy; magnetic resonance imaging; voxel based morphometry; diffusion tensor imaging

This article has been cited by other articles:

				B. Borroni, V. Garibotto, C. Agosti, S. M. Brambati, G. Bellelli, R. Gasparotti, A. Padovani, and D. Perani White Matter Changes in Corticobasal Degeneration Syndrome and Correlation With Limb Apraxia Arch Neurol, June 1, 2008; 65(6): 796 - 801. [Abstract] [Full Text] [PDF]

				D.H. Shin, B.S. Han, H.S. Kim, and P.H. Lee Diffusion Tensor Imaging in Patients With Essential Tremor AJNR Am. J. Neuroradiol., January 1, 2008; 29(1): 151 - 153. [Abstract] [Full Text] [PDF]

				M.-C. Chou, C.-Y. Wang, H.-S. Liu, H.-W. Chung, and C.-Y. Chen Pseudolesions Arising from Unfolding Artifacts in Diffusion Imaging with Use of Parallel Acquisition: Origin and Remedies AJNR Am. J. Neuroradiol., June 1, 2007; 28(6): 1099 - 1101. [Abstract] [Full Text] [PDF]

				B. Borroni, S. M. Brambati, C. Agosti, S. Gipponi, G. Bellelli, R. Gasparotti, V. Garibotto, M. Di Luca, P. Scifo, D. Perani, et al. Evidence of White Matter Changes on Diffusion Tensor Imaging in Frontotemporal Dementia Arch Neurol, February 1, 2007; 64(2): 246 - 251. [Abstract] [Full Text] [PDF]

				From the Library Br. J. Ophthalmol., July 1, 2006; 90(7): 930 - 930. [Full Text] [PDF]