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PAPER |
1 Department of Neurology, Johannes-Gutenberg University, Mainz, Germany
2 Department of Psychosomatic Medicine and Psychotherapy, Johannes-Gutenberg University
3 Department of Psychology, Georg-August University, Göttingen, Germany
Correspondence to:
Correspondence to:
Dr Christoph Best
Department of Neurology, Johannes-Gutenberg University, Langenbeckstraße 1, 55101 Mainz, Germany; bestc{at}uni-mainz.de
Background: The high coincidence of organic vestibular and somatoform vertigo syndromes has appeared to support pathogenic models showing a strong linkage between them. It was hypothesised that a persisting vestibular dysfunction causes the development of anxiety disorders.
Objective: To determine the relation between vestibular deficits and somatoform vertigo disorders in an interdisciplinary prospective study.
Methods: Participants were divided into eight diagnostic groups: healthy volunteers (n = 26) and patients with benign paroxysmal positioning vertigo (BPPV, n = 11), vestibular neuritis (n = 11), Menière’s disease (n = 7), vestibular migraine (n = 15), anxiety (n = 23), depression (n = 12), or somatoform disorders (n = 22). Neuro-otological diagnostic procedures included electro-oculography with rotatory and caloric testing, orthoptic examination with measurements of subjective visual vertical (SVV) and ocular torsion, and a neurological examination. Psychosomatic diagnostic procedures comprised interviews and psychometric instruments.
Results: Patients with BPPV (35.3%) and with vestibular neuritis (52.2%) had pathological test values on caloric irrigation (p<0.001). Otolith dysfunction with pathological tilts of SVV and ocular torsion was found only in patients with vestibular neuritis (p<0.001). Patients with Menière’s disease, vestibular migraine, and psychiatric disorders showed normal parameters for vestibular testing but pathological values for psychometric measures. There was no correlation between pathological neurological and pathological psychometric parameters.
Conclusions: High anxiety scores are not a result of vestibular deficits or dysfunction. Patients with Menière’s disease and vestibular migraine but not vestibular deficits showed the highest psychiatric comorbidity. Thus the course of vertigo syndromes and the possibility of a pre-existing psychopathological personality should be considered pathogenic factors in any linkage between organic and psychometric vertigo syndromes.
Abbreviations: BPPV, benign paroxysmal positioning vertigo; DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, fourth edition; EOG, electro-oculography; HADS, hospital anxiety and depression scale; OT, ocular torsion; SCID, structural clinical interview for DSM-IV axis I disorders; SOMS, screening for somatoform disorders score; SVV, subjective visual vertical; VHQ, vertigo handicap questionnaire; VSS, vertigo symptom scale
Keywords: dizziness; vertigo; migraine; anxiety; depression
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