HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) All Versions of this Article: jnnp.2005.077875v1 77/7/850    most recent Submit a response Read responses to this article Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nakayama, N Articles by Iwama, T Search for Related Content PubMed PubMed Citation Articles by Nakayama, N Articles by Iwama, T Topic Collections Relevant Article

Evidence for white matter disruption in traumatic brain injury without macroscopic lesions

¹ Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, Minokamo City, Gifu, Japan
² Department of Neurosurgery, Gifu University Graduate School of Medicine, Gifu

Correspondence to:
Correspondence to:
Dr Nakayama Noriyuki
630 Shimokobi, Kobi-machi, Minokamo City, Gifu 505 0034, Japan; doctor.1{at}jasmine.ocn.ne.jp

Background: Non-missile traumatic brain injury (nmTBI) without macroscopically detectable lesions often results in cognitive impairments that negatively affect daily life.

Aim: To identify abnormal white matter projections in patients with nmTBI with cognitive impairments using diffusion tensor magnetic resonance imaging (DTI).

Methods: DTI scans of healthy controls were compared with those of 23 patients with nmTBI who manifested cognitive impairments but no obvious neuroradiological lesions. DTI was comprised of fractional anisotropy analysis, which included voxel-based analysis and confirmatory study using regions of interest (ROI) techniques, and magnetic resonance tractography of the corpus callosum and fornix.

Results: A decline in fractional anisotropy around the genu, stem and splenium of the corpus callosum was shown by voxel-based analysis. Fractional anisotropy values of the genu (0.47), stem (0.48), and splenium of the corpus callosum (0.52), and the column of the fornix (0.51) were lower in patients with nmTBI than in healthy controls (0.58, 0.61, 0.62 and 0.61, respectively) according to the confirmatory study of ROIs. The white matter architecture in the corpus callosum and fornix of patients with nmTBI were seen to be coarser than in the controls in the individual magnetic resonance tractography.

Conclusions: Disruption of the corpus callosum and fornix in patients with nmTBI without macroscopically detectable lesions is shown. DTI is sensitive enough to detect abnormal neural fibres related to cognitive dysfunction after nmTBI.

Abbreviations: DTI, diffusion tensor magnetic resonance imaging; MMSE, Mini-Mental State Examination; nmTBI, non-missile traumatic brain injury, PASAT, Paced Auditory Serial Addition Test; ROI, region of interest; SPM, statistical parametric mapping; WAIS—R, Wechsler Adult Intelligence Scale—Revised; WMS—R, Wechsler Memory Scale—Revised

Relevant Article

Relationship between regional cerebral metabolism and consciousness disturbance in traumatic diffuse brain injury without large focal lesions: an FDG-PET study with statistical parametric mapping analysis

N Nakayama, A Okumura, J Shinoda, T Nakashima, and T Iwama
J. Neurol. Neurosurg. Psychiatry 2006 77: 856-862. [Abstract] [Full Text] [PDF]

This article has been cited by other articles:

				D.R. Rutgers, P. Fillard, G. Paradot, M. Tadie, P. Lasjaunias, and D. Ducreux Diffusion Tensor Imaging Characteristics of the Corpus Callosum in Mild, Moderate, and Severe Traumatic Brain Injury AJNR Am. J. Neuroradiol., October 1, 2008; 29(9): 1730 - 1735. [Abstract] [Full Text] [PDF]

				J. Y. Wang, K. Bakhadirov, M. D. Devous Sr, H. Abdi, R. McColl, C. Moore, C. D. Marquez de la Plata, K. Ding, A. Whittemore, E. Babcock, et al. Diffusion Tensor Tractography of Traumatic Diffuse Axonal Injury Arch Neurol, May 1, 2008; 65(5): 619 - 626. [Abstract] [Full Text] [PDF]

				D.R. Rutgers, F. Toulgoat, J. Cazejust, P. Fillard, P. Lasjaunias, and D. Ducreux White Matter Abnormalities in Mild Traumatic Brain Injury: A Diffusion Tensor Imaging Study AJNR Am. J. Neuroradiol., March 1, 2008; 29(3): 514 - 519. [Abstract] [Full Text] [PDF]

				A. Sidaros, A. W. Engberg, K. Sidaros, M. G. Liptrot, M. Herning, P. Petersen, O. B. Paulson, T. L. Jernigan, and E. Rostrup Diffusion tensor imaging during recovery from severe traumatic brain injury and relation to clinical outcome: a longitudinal study Brain, February 1, 2008; 131(2): 559 - 572. [Abstract] [Full Text] [PDF]

				C. L. Mac Donald, K. Dikranian, P. Bayly, D. Holtzman, and D. Brody Diffusion Tensor Imaging Reliably Detects Experimental Traumatic Axonal Injury and Indicates Approximate Time of Injury J. Neurosci., October 31, 2007; 27(44): 11869 - 11876. [Abstract] [Full Text] [PDF]

				M. F. Kraus, T. Susmaras, B. P. Caughlin, C. J. Walker, J. A. Sweeney, and D. M. Little White matter integrity and cognition in chronic traumatic brain injury: a diffusion tensor imaging study Brain, October 1, 2007; 130(10): 2508 - 2519. [Abstract] [Full Text] [PDF]

				J Albrecht, P R Dellani, M J Muller, I Schermuly, M Beck, P Stoeter, A Gerhard, and A Fellgiebel Voxel based analyses of diffusion tensor imaging in Fabry disease J. Neurol. Neurosurg. Psychiatry, September 1, 2007; 78(9): 964 - 969. [Abstract] [Full Text] [PDF]

eLetters: