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Insular cortical ischaemia does not independently predict acute hypertension or hyperglycaemia within 3 h of onset

¹ Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
² Department of Clinical Geratology, University of Oxford, Oxford, UK

Correspondence to:
Correspondence to:
Michael D Hill
Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada; michael.hill{at}calgaryhealthregion.ca

ABSTRACT
Objectives: To test the hypothesis that insular cortical ischaemia is associated with acute hypertension and hyperglycaemia.

Methods: From the Canadian Activase for Stroke Effectiveness Study, which included only patients treated with thrombolysis hyperacutely (ie, within 3 h of onset of stroke), 966 patients were identified with ischaemia affecting (n = 685), or sparing (n = 281), the insular cortex. Demographic and clinical data, pretreatment indices of blood pressure, blood glucose, atrial fibrillation, and clinical imaging and outcome measures were compared between the two groups. Multivariable linear regression was used to assess predictors of systolic blood pressure and glucose levels before thrombolysis.

Results: Pretreatment hypertension (p = 0.009), but not hyperglycaemia (p = 0.32), was predicted by insular ischaemia in univariable linear regression analyses. After adjusting for other factors, however, insular cortical ischaemia was not found to be an independent predictor for acute hypertension or hyperglycaemia.

Conclusions: Raised blood pressure or serum glucose levels in hyperacute (<3 h) cerebral ischaemia is not independently predicted by insular involvement. Several hours are required for sympathetic manifestations of insular ischaemia to evolve.

Abbreviations: ASPECTS, Alberta Stroke Program Early CT Score; NIHSS, National Institute of Health Stroke Scale; SBP, systolic blood pressure

Relevant Article

Cardiovascular and metabolic changes in insular infarcts: a delayed phenomenon?

M Pasquini and D Leys
J. Neurol. Neurosurg. Psychiatry 2006 77: 813. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

				M Pasquini and D Leys Cardiovascular and metabolic changes in insular infarcts: a delayed phenomenon? J. Neurol. Neurosurg. Psychiatry, July 1, 2006; 77(7): 813 - 813. [Full Text] [PDF]