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Compensatory cortical activation during performance of an attention task by patients with diffuse axonal injury: a functional magnetic resonance imaging study

¹ Hiroshima Higher Brain Function Center, Taguchi, Saijo, Higashihiroshima, Japan
² Laboratory of Psychology, Graduate School of Education, Hiroshima University, Kagamiyama, Saijo, Higashihiroshima, Japan

Correspondence to:
Correspondence to:
M Maruishi
Higher Brain Function Center, Hiroshima Prefectural Rehabilitation Center, 295-3, Taguchi, Saijo, Higashihiroshima, 739-0036, Japan; maruishi{at}rehab-hiroshima.gr.jp

Objective: To determine how cortical compensation occurs in higher cognitive systems during the recovery phase of diffuse axonal injury (DAI).

Design: 12 right-handed patients with a magnetic resonance imaging (MRI) lesion pattern compatible with pure DAI were identified. Pure DAI was defined as finding of traumatic microbleeds on T2*-weighted gradient-echo images in the absence of otherwise traumatic or non-traumatic MRI abnormalities. 12 matched healthy controls were also enrolled. Functional magnetic resonance imaging (fMRI) was used to assess brain activation during a working memory test (Paced Visual Serial Attention Test (PVSAT)).

Results: No significant group differences were observed in reaction times for the PVSAT. Although patients with pure DAI committed a few errors during the PVSAT, controls respond correctly to each probe. Controls showed activations in the left frontal gyrus, left parietal gyrus and right inferior parietal gyrus. Patients with pure DAI showed activations in the left inferior frontal gyrus, right inferior frontal gyrus and right middle frontal gyrus. Between-group analysis of the PVSAT task showed significantly greater activation of the right inferior frontal gyrus (BA 45) and right middle frontal gyrus (BA 9) in patient with pure DAI versus controls.

Conclusions: Patients with pure DAI require compensatory activation of the contralateral (right) prefrontal region to carry out activities similar to healthy controls. These findings provide further evidence for the adaptive capacity of neuronal systems and brain plasticity during the recovery stages of DAI.

Abbreviations: CRT, Choice Reaction Test; DAI, diffuse axonal injury; fMRI, functional magnetic resonance imaging; MNI, Montreal Neurological Institute; MRI, magnetic resonance imaging; PASAT, Paced Auditory Serial Attention Task; PVSAT, Paced Visual Serial Attention Test; TBI, traumatic brain injury; TMBs, traumatic microbleeds

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