Journal of Neurology, Neurosurgery, and Psychiatry 2007;78:760-763
SHORT REPORT
Post-surgical changes in brain metabolism detected by magnetic resonance spectroscopy in normal pressure hydrocephalus: results of a pilot study
1 Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Spain
2 Department of Neurosurgery, Vall d’Hebron University Hospital, Autonomous University of Barcelona, Barcelona, Spain
3 August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain
4 Department of Neuroradiology, Hospital Clínic i Provincial de Barcelona, Barcelona, Spain
Correspondence to:
Correspondence to:
Dr M A Poca
Neurosurgery Department, Vall d’Hebron University Hospital, Passeig Vall d’Hebron 119-129, 08035 Barcelona, Spain; 26382app{at}comb.es
Background: Adult normal pressure hydrocephalus (NPH) is one of the few potentially treatable causes of dementia. Some morphological and functional abnormalities attributed to hydrocephalus improve following treatment.
Objectives: We focused on analysis of changes in cerebral metabolites using proton magnetic resonance spectroscopy (1H-MRS) after NPH treatment, and its clinical and cognitive correlation.
Methods: 1H-MRS, neuropsychological and clinical status examinations were performed before and 6 months after shunting in 12 adults with idiopathic NPH. We obtained N-acetyl-aspartate (NAA), choline (Cho), myoinositol (MI) and creatine (Cr) values.
Results: After surgery, NAA/Cr was significantly increased. Moreover, NAA/Cr values were related to cognitive deterioration.
Conclusion: MRS could be a marker of neuronal dysfunction in NPH.
Abbreviations: Cr, creatine; Cho, choline; 1H-MRS, proton magnetic resonance spectroscopy; MI, myoinositol; MMSE, Mini-Mental State Examination; NAA, N-acetyl-aspartate; NPH, normal pressure hydrocephalus
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
jnnp.2006.088450v1
78/7/760 most recent - Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
-
Memory disorders (neurology)
-
Hydrocephalus
-
Memory disorders (psychiatry)
-
Radiology
- Radiology (diagnostics)
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
