SHORT REPORTS

Factors influencing surgical outcome in patients with focal cortical dysplasia

S Fauser¹, T Bast², D-M Altenmüller¹, J Schulte-Mönting³, K Strobl⁴, B J Steinhoff⁴, J Zentner⁵ and A Schulze-Bonhage¹

¹ Epilepsy Centre, University of Freiburg, Germany
² Department of Paediatric Neurology, University of Heidelberg, Germany
³ Faculty for Mathematics and Physics, University of Freiburg, Germany
⁴ Epilepsy Centre Kork, Kehl-Kork, Germany
⁵ Department of Neurosurgery, University of Freiburg, Germany

Correspondence to:
S Fauser, Epilepsy Centre, University of Freiburg, Breisacher Str 64, 79106 Freiburg, Germany; susanne.fauser{at}uniklinik-freiburg.de

A total of 120 patients with histologically proven focal cortical dysplasias (FCD) were retrospectively analysed for prognostic factors for successful epilepsy surgery. Multivariate data analyses showed that older age at epilepsy surgery, occurrence of secondarily generalised seizures and a multilobar extent of the dysplasia were significant negative predictors. In univariate analyses, longer duration of epilepsy, need for intracranial EEG recordings and incomplete resection of the FCD were factors which significantly reduced the chance of becoming seizure free. Histological subtype of the FCD and age at epilepsy onset had no significant predictive value. These findings strongly suggest early consideration of epilepsy surgery in FCD patients.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Fauser, S., Sisodiya, S. M., Martinian, L., Thom, M., Gumbinger, C., Huppertz, H.-J., Hader, C., Strobl, K., Steinhoff, B. J., Prinz, M., Zentner, J., Schulze-Bonhage, A. (2009). Multi-focal occurrence of cortical dysplasia in epilepsy patients. Brain 0: awp145v1-awp145 [Abstract] [Full Text]  
• Asano, E., Juhasz, C., Shah, A., Sood, S., Chugani, H. T. (2009). Role of subdural electrocorticography in prediction of long-term seizure outcome in epilepsy surgery. Brain 132: 1038-1047 [Abstract] [Full Text]  
• Kim, D. W., Lee, S. K., Chu, K., Park, K. I., Lee, S. Y., Lee, C. H., Chung, C. K., Choe, G., Kim, J. Y. (2009). Predictors of surgical outcome and pathologic considerations in focal cortical dysplasia. Neurology 72: 211-216 [Abstract] [Full Text]  
• Salamon, N., Kung, J., Shaw, S. J., Koo, J., Koh, S., Wu, J. Y., Lerner, J. T., Sankar, R., Shields, W. D., Engel, J. Jr, Fried, I., Miyata, H., Yong, W. H., Vinters, H. V., Mathern, G. W. (2008). FDG-PET/MRI coregistration improves detection of cortical dysplasia in patients with epilepsy. Neurology 71: 1594-1601 [Abstract] [Full Text]