HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) web only appendix All Versions of this Article: jnnp.2007.122853v1 79/2/176    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Salmon, E Articles by Herholz, K Search for Related Content PubMed PubMed Citation Articles by Salmon, E Articles by Herholz, K

A comparison of unawareness in frontotemporal dementia and Alzheimer’s disease

¹ Cyclotron Research Center, University of Liege, Liège, Belgium
² Vita Salute San Raffaele University, IRCCS H San Raffaele, IBFM-CNR, Milan, Italy
³ Department of Neurology, University of Cologne, Germany
⁴ Department of Psychiatry and Psychotherapy, Dresden University of Technology, Dresden, Germany
⁵ Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
⁶ Wolfson Molecular Imaging Centre, University of Manchester, UK

Correspondence to:
Eric Salmon, Cyclotron Research Center, University of Liège, B30 Sart Tilman, 4000 Liège, Belgium; eric.salmon{at}ulg.ac.be

Background: Loss of insight is a core diagnostic feature of frontotemporal dementia (FTD) and anosognosia is frequently reported in Alzheimer’s disease (AD).

Aim: To compare unawareness (anosognosia) for different symptoms, measured with a discrepancy score between patient’s and caregiver’s assessment, in AD and FTD.

Method: In a prospective, multi-centre study, 123 patients with probable AD, selected according to the NINCDS-ADRDA procedure, were matched for age, sex, education, disease duration and dementia severity to patients with FTD (n = 41), selected according to international consensus criteria. A research complaint questionnaire was used to obtained patient’s and caregiver’s assessment concerning neuropsychological and behavioural symptoms. Data were compared in each group and between groups. Unawareness (measured by discrepancy scores) was compared between patients with AD and FTD.

Results: The caregivers generally assessed symptoms more severely than did patients, but both patient groups reported changes in affect (depressive mood or irritability) as their caregivers did. Unawareness was greater in patients with FTD than in patients with AD for language and executive difficulties, and for changes in behaviour and daily activities.

Conclusion: The main finding is that unawareness was observed in both patients with FTD and patients with AD for most clinical domains. However, qualitative and quantitative differences showed that lack of awareness was greater in patients with FTD.

This article has been cited by other articles:

				M. F. Mendez, E. C. Lauterbach, S. M. Sampson, and ANPA Committee on Research An Evidence-Based Review of the Psychopathology of Frontotemporal Dementia: A Report of the ANPA Committee on Research J Neuropsychiatry Clin Neurosci, May 1, 2008; 20(2): 130 - 149. [Abstract] [Full Text] [PDF]