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This Article Full Text Full Text (PDF) All Versions of this Article: jnnp.2007.116830v1 79/4/387    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Google Scholar Articles by Gjerstad, M D Articles by Larsen, J P PubMed PubMed Citation Articles by Gjerstad, M D Articles by Larsen, J P

Occurrence and clinical correlates of REM sleep behaviour disorder in patients with Parkinson’s disease over time

¹ The Norwegian Centre for Movement Disorders, Stavanger, Norway
² Department of Neurology, Stavanger University Hospital, Stavanger, Norway
³ Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA
⁴ Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway
⁵ Department of Psychiatry, Stavanger University Hospital, Stavanger, Norway
⁶ Institute of Clinical Medicine, University of Bergen, Bergen, Norway

Correspondence to:
Michaela D Gjerstad, The Norwegian Centre for Movement Disorders, Stavanger, Norway, PB 8100, N-4068 Stavanger, Norway; gjmi{at}sus.no

Methods: 231 patients with PD were included in a population-based prevalence study in 1993. Patients were then followed prospectively and reexamined after 4 and 8 years. Semi-structured interviews for information on clinical and demographic data were applied at all study visits. Standardised rating scales of parkinsonism, depression and cognitive impairment were used. The diagnosis of probable RBD (pRBD) was based on a sleep questionnaire. Proportional-odds ordinal logistic regression models for clustered data were used to study the relationship between pRBD and various demographic and clinical variables.

Results: 231 patients were evaluated for RBD in 1993 and, after 4 and 8 years, 142 and 89 patients, respectively, were available for re-evaluation. The frequency of pRBD varied from 14.6% to 27% during the study period. Probable RBD was related to male gender, higher dopaminergic treatment and less severe parkinsonism.

Conclusion: We found that the frequency of pRBD varied over time and that it is associated with male gender, less parkinsonism and higher levodopa equivalent dose. Our findings indicate that dopaminergic therapy may contribute to the expression of RBD and that RBD is symptomatic in earlier stages of PD.

Keywords: Parkinson’s disease; RBD; prospective; sleep