HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) All Versions of this Article: jnnp.2007.136929v1 79/5/590    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Google Scholar Articles by Klein, K M Articles by Hamer, H M PubMed PubMed Citation Articles by Klein, K M Articles by Hamer, H M

Topiramate, nutrition and weight change: a prospective study

¹ Interdisciplinary Epilepsy-Centre, Department of Neurology, Philipps University, Marburg, Germany
² Interdisciplinary Epilepsy-Centre, Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
³ Department of Child and Adolescent Psychiatry, University Duisburg-Essen, Germany

Correspondence to:
Dr K M Klein, Interdisciplinary Epilepsy-Centre, Department of Neurology, Philipps-University Marburg, Rudolf-Bultmann-Str 8, 35033 Marburg, Germany; klein.km{at}staff.uni-marburg.de

Methods: 22 patients with epilepsy who were started on TPM were prospectively followed for 6 months and contacted again after a mean follow-up time of 37.1 months.

Results: Body mass index (BMI) loss occurred in 59% of patients, with a mean weight loss of 9.5 kg after 6 months while receiving TPM without further weight loss at the long term follow-up. Weight loss was associated with reduction in appetite without affecting food composition. Predictors for BMI loss after 6 months were high initial BMI and body fat. After 3 weeks of treatment with TPM, the recorded parameters did not predict BMI loss but at 3 months, weight loss, reduction of appetite and amount of food intake were predictive for the amount of BMI loss after 6 months.