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J Neurol Neurosurg Psychiatry 1998;65:291-300 ( September )

Review: Neurology and medicine

Neurology and the gastrointestinal system

G D Perkin,^a I Murray-Lyon^b

^a Department of Neuroscience and Psychological Medicine, The Hammersmith Trust Hospitals, Charing Cross Hospital, London, UK, ^b Department of Gastroenterology, Chelsea and Westminster Healthcare NHS Trust, Chelsea and Westminster Hospital, London, UK

Correspondence to: Dr GD Perkin, Department of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, Fulham Palace Road,London, W6 8RF, UK.

Received 11 February 1998 and in revised form 15 May 1998; Accepted 15 May 1998

The first 150 words of the full text of this article appear below.

	Introduction

The interrelation of neurology and the gastrointestinal system includes defects of gut innervation, primary disorders of the nervous system (or muscle) which lead to gastrointestinal symptomsfor example, dysphagiaand, finally, certain gut disorders which include neurological features in their clinical range. The first of this trio will be discussed only briefly in this review, the second and third in more detail.

	Defects of innervation

ACHALASIA
Achalasia is characterised by an absence of peristalsis in the oesophageal body accompanied by a failure of relaxation of the lower oesophageal sphincter.¹ Although the condition can be secondary to other disease processesfor example, Chagas' diseasein Europeans it is usually a primary disorder. Differing opinions have been expressed as to whether the problem of innervation rests in the dorsal motor vagal nucleus, the vagus itself, or in the intrinsic innervation of the oesophagus, with most evidence favouring the last explanation. By the time of oesophageal . . . [Full text of this article]

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