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a Diabetic
Department, King's College Hospital, London, UK, b University Department of Clinical Neurosciences, Royal Free
Hospital School of Medicine, London, UK
Correspondence to: Professor PK Thomas, University Department of Clinical Neurosciences, Royal Free Hospital School of Medicine, Rowland Hill Street, London NW3 2PF, UK. Telephone 0044 171 830 2869; fax 0044171 431 1577.
Received 10 March 1998 and in revised form 19 May 1998;
Accepted 1
June 1998
| The first 150 words of the full text of this article appear below. |
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Introduction |
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Diabetes mellitus is a disorder in which the concentration of
blood glucose is persistently raised above the normal range. It occurs
either because of a lack of insulin or because of the presence of
factors which oppose the action of insulin. Hyperglycaemia results from
insufficient insulin action. There are many associated metabolic
abnormalities
notably, the development of hyperketonaemia when there
is a severe lack of insulin, together with alterations of fatty acids,
lipids, and protein turnover. Diabetes is a permanent condition in all
but a few special situations in which it can be transient.
A wide variety of disturbances affecting the central and peripheral
nervous systems, either directly or indirectly, may be encountered in
patients with diabetes mellitus. This short selective review
concentrates on recent progress in the delineation of the clinical
features of the neurological syndromes related to diabetes and their
management. It will deal, sequentially, with the classification
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