J Neurol Neurosurg Psychiatry 1998;65:801-802 ( November )
Letters to the editor
Postpartum cerebral venous thrombosis, congenital
protein C deficiency, and activated protein C resistance due to
heterozygous factor V Leiden mutation
| The first 150 words of the full text of this article appear below. |
Activated protein C resistance (APC-R) due to factor V
Leiden mutation is the most common thrombophilia associated with
cerebral venous thrombosis. It is present in 10% to 20% of patients
but usually in association with other constitutional or acquired
prothrombotic conditions.1 We present a case of postpartum
cerebral venous thrombosis in a patient with protein C deficiency
and APC-R due to heterozygous factor V Leiden mutation. In addition
to puerperium, the role of intravenous steroids is questioned in this case.
A 33 year old woman was admitted because of severe subacute headaches,
nausea, and drowsiness. She was not taking oral contraceptives. Her
medical history disclosed recent delivery of a second child 3 weeks
before and an asthma attack 5 days before entry, treated with
intravenous methylprednisolone (120 mg daily). Family history disclosed
that the patient's mother had had postpartum lower limb deep vein
thrombosis. On admission, clinical examination disclosed papilloedema.
There was no fever . . . [Full text of this article]
