J Neurol Neurosurg Psychiatry 2001;71:560-561
( October )
Letters to the editor
Early onset epileptic auditory
and visual agnosia with spontaneous recovery associated with
Tourette's syndrome
| The first 150 words of the full text of this article appear below. |
Potentially recoverable impairments of cognition, behaviour,
and movement are integral to early onset epilepsies.1 The classic epilepsy syndrome presenting as developmental regression is
Landau-Kleffner syndrome, in which receptive aphasia and behavioural, cognitive, and motor impairments occur with centrotemporal discharges enhanced in sleep.2 We report a novel biography of domain
specific impairments and recovery in infantile spasms.
At 12 years of age the patient presented with Tourette's syndrome,
with an extraordinary developmental history of epilepsy, regression,
and recovery. He was normal until 6 months, being socially responsive,
visually alert, reaching and transferring objects. Development slowed
from 7 months. There was no relevant family history.
At 8 months runs of typical symmetric flexion spasms at intervals of
5-10 seconds, 3-4 times/day began. The EEG was disorganised, with
bilateral very high amplitude (450 µV) activity and more left
temporal area multifocal spikes and polyspikes, approaching classic
hypsarrhythmia. ACTH (10 units daily and 40 units daily from 10-12
months) stopped the . . . [Full text of this article]
