Introduction

T he neurologist is often required to evaluate the unconscious patient from both the diagnostic and prognostic perspective. Knowledge of the anatomical basis of coma is essential for competent evaluation but must be combined with an understanding of the many, often multi-factorial, medical conditions that result in impaired consciousness.

Consciousness is a state of awareness of self and the environment. This state is determined by two separate functions:

• awareness (content of consciousness)
• arousal (level of consciousness ).

These are dependant upon separate physiological and anatomical systems. Coma is caused by disordered arousal rather than impairment of the content of consciousness, this being the sum of cognitive and affective mental function, dependent on an intact cerebral cortex. The absence of all content of consciousness is the basis for the vegetative state.

Arousal depends on an intact ascending reticular activating system and connections with diencephalic structures. Like awareness, arousal is not an all . . . [Full text of this article]